We report the first well documented case of subcutaneous phaeohyphomycotic infection caused by Phialophora verrucosa in India. Examination of the biopsied tissue from an ulcerating lesion on the shin of the left leg of a 45-year-old woman from Bombay, India, showed numerous dematiaceous, septate, branching hyphal elements and thick-walled cells characteristic of phaeohyphomycosis. Cultures of the scrapings from the lesion and of the biopsied tissue yielded a pigmented fungus that was identified as P. verrucosa. Initial treatment with fluconazole followed by oral itraconazole for 30 days and local application of a copper sulphate solution resulted in complete resolution of the lesion. Treatment with itraconazole was continued for an additional 3 months after complete healing. No new lesions developed and the patient did not show jaundice, hepatosplenomegaly or any other signs of toxicity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0163-4453(98)93666-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Treatment-Resistant Chromoblastomycosis Successfully Managed With Surgical Excision.
Cureus
November 2024
Dermatology, University of California Davis Medical Center, Sacramento, USA.
Chromoblastomycosis is an uncommon, chronic granulomatous fungal infection of the skin and subcutaneous tissue. Chromoblastomycosis is most commonly caused by the traumatic inoculation of dematiaceous (pigmented) fungi, most commonly species, species, and species. Chromoblastomycosis usually affects agricultural workers in tropical and subtropical climates.
View Article and Find Full Text PDFMetagenome-based characterization of the gut bacteriome, mycobiome, and virome in patients with chronic hepatitis B-related liver fibrosis.
Front Microbiol
October 2024
Centre for Translational Medicine, Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.
Introduction: The gut microbiota is believed to be directly involved in the etiology and development of chronic liver diseases. However, the holistic characterization of the gut bacteriome, mycobiome, and virome in patients with chronic hepatitis B-related liver fibrosis (CHB-LF) remains unclear.
Methods: In this study, we analyzed the multi-kingdom gut microbiome (i.
Chromoblastomycosis: A Single Centre Clinical Laboratory Experience of Seven Years (2016-2022) and Literature Review From Pakistan.
Mycoses
September 2024
Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
Article Synopsis
- Chromoblastomycosis (CBM) is a chronic skin and tissue infection that has been documented in Pakistan, highlighting varied demographics and treatment outcomes.
- A study analyzed 16 cases of CBM from 2016 to 2022, revealing that most patients were young males, predominantly affected in the lower extremities, and showing specific histopathological features.
- The findings emphasize the need for increased awareness of CBM among healthcare providers in Pakistan, particularly for patients with relevant histories, and call for enhanced collaboration among clinicians and lab specialists for timely diagnosis and treatment.
Enhancing the thermal stability and activity of zearalenone lactone hydrolase to promote zearalenone degradation via semi-rational design.
Enzyme Microb Technol
October 2024
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:
Article Synopsis
- - Zearalenone (ZEN) is a harmful fungal toxin linked to reproductive issues in both animals and humans, and its removal is crucial for health and safety.
- - Current methods using ZEN lactonases struggle with thermal stability, but a new engineered enzyme variant, I160Y-G242S, shows about 40% activity retention at 55℃ after 10 minutes, making it the most heat-tolerant ZEN hydrolase reported.
- - The I160Y-G242S variant also exhibits twice the effectiveness compared to its predecessor, thanks to enhanced stability and improved interactions with its substrate, making it a promising option for ZEN degradation in industrial applications.
A comparison of the performance of bacterial biofilters and fungal-bacterial coupled biofilters in BTE-X removal.
PeerJ
June 2024
School of Environmental Engineering, Gansu Forestry Polytechnic, Tianshui, China.
Background: Conventional biofilters, which rely on bacterial activity, face challenges in eliminating hydrophobic compounds, such as aromatic compounds. This is due to the low solubility of these compounds in water, which makes them difficult to absorb by bacterial biofilms. Furthermore, biofilter operational stability is often hampered by acidification and drying out of the filter bed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!