Introduction: A retrospective analysis of the Program for Leprosy Control in four counties of Mato Grosso State, on the Brazil-Bolivian frontier, has been undertaken in the present study.
Population And Methods: The health care service records of all patients registered by the Programs for Leprosy Control during the period from the beginning of their activities up to 1990 inclusive were checked. Final analysis was performed by epidemiological and operational indicators for the follow-up of control activities of Leprosy Control, as defined by the World Health Organization.
Results: An inadequate recording of information given by the patient was detected in more than half of all cases. The prevalence of leprosy varied from 15 to 48/10,000, in the period studied. The annual detection rate of new cases was 112/100,000 in 1990.
Conclusion: The results suggest a high endemicity pattern for leprosy in the region. With regard to operational indicators our finding showed inadequate practice regarding all the activities of the program probably worsened by the poor qualification of the health workers involved in the assistance given.
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http://dx.doi.org/10.1590/s0034-89101997000300009 | DOI Listing |
Background: In Nigeria, men constitute over half of the people notified with tuberculosis (TB), experience longer delays before reaching care, and are estimated to account for two thirds of people who miss out on care. The higher TB risk and burden in men has implications for the whole population and reaching them earlier with TB services will reduce onward transmission in households, communities, and workplaces. The absence of a comprehensive guidance and the lack of substantial empirical evidence on TB care approaches that are responsive to the needs of men in Nigeria exacerbates this problem.
View Article and Find Full Text PDFTrop Med Int Health
January 2025
Programa de Pós-graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Objectives: The purpose of this study was to determine reference points for thermal perception in cutaneous lesions of leprosy, a disease caused by Mycobacterium leprae characterised by hypoesthesia in skin lesions due to nerve and Schwann cell infection. Early diagnosis is essential to control transmission and effectively treat the disease.
Methods: Quantitative thermal testing (QTT) has been proposed as a valuable tool for early detection of the disease, initiation of treatment, and monitoring of nerve damage.
PLoS Negl Trop Dis
January 2025
Marie Adelaide Leprosy Center, Karachi, Pakistan.
Background: Recent epidemiological data shows significant rates of grade 2 disability at point-of-diagnosis among new leprosy cases in Pakistan. This indicates a feature of extensive diagnostic delay; the disability burden appears unmoving and disproportionate to the falling leprosy incidence rates. Therefore, this study was required to understand reasons for delay in diagnosis and treatment of leprosy.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
Laboratory of Molecular Pharmacology and Bioactive Compounds, Postgraduate Program in Health Sciences, São Francisco University, 215 São Francisco de Assis Avenue, Bragança Paulista 12916-900, São Paulo, Brazil.
Treating chronic wounds incurs substantial costs for Brazil's Unified Health System. Natural compounds, particularly propolis, are increasingly explored as low-cost alternatives due to their healing properties. Brazilian green propolis, distinct in its chemical composition, has garnered scientific interest.
View Article and Find Full Text PDFFront Immunol
January 2025
Programa Multicêntrico de Bioquímica e Biologia Molecular/PMBqBM - Universidade Federal de Juiz de Fora - UFJF, Governador Valadares, MG, Brazil.
Introduction: Leprosy, a chronic infectious disease, is closely linked to the host immune response. According to the WHO, leprosy patients (L) and household contacts (HHC) are classified into subgroups: paucibacillary (PB) and multibacillary (MB), witch reflect the degree of infection in patients and the level of exposure of their contacts. The main goal of this study was to: i) establish a comprehensive overview of soluble mediator signatures of PBMCs upon antigen-specific stimuli and ii) identify whether the chemokine (CH) and cytokine (CY) signatures were associated with distinct clinical manifestations in (L) and immune response profiles in (HHC).
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