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Neuromuscular Electrostimulation Increases Microcirculatory Flux in Mixed Etiology Leg Ulcers.
Adv Skin Wound Care
January 2025
Keith Gordon Harding, Mb ChB, CBE, FRCGP, FRCP, FRCS, FLSW, is Professor Emeritus Cardiff University, Cardiff, Wales; Adjunct Professor Monash University Malaysia, Subang Jaya, Selangor, Malaysia; and Co-Founder and Editor in Chief of the International Wound Journal. Melissa Blow, BSc, is Principal Podiatrist, South East Wales Vascular Network, Aneurin Bevan University Health Board, Cardiff, Wales. Faye Ashton, BSc, is Vascular Research Nurse, Leicester Biomedical Research Centre, Glenfield University Hospital, Leicester, United Kingdom. David Bosanquet, MD, is Consultant Vascular Surgeon, South East Wales Vascular Network, Aneurin Bevan University Health Board. Acknowledgments: The authors acknowledge the assistance of Firstkind Ltd, Hawk House, Peregrine Business Park, Gomm Road, High Wycombe, United Kingdom HP13 7DL for sponsoring the study (grant ref: FSK-SPECKLE-001) and provided the NMES devices for the trial. Keith Harding has received payments for consulting work from Firstkind Ltd. The authors have disclosed no other financial relationships related to this article. Submitted November 28, 2023; accepted in revised form April 17, 2024.
Objective: To determine if intermittent neuromuscular electrostimulation (NMES) of the common peroneal nerve increases microvascular flow and pulsatility in and around the wound bed of patients with combined venous and arterial etiology.
Methods: Seven consenting participants presenting with mixed etiology leg ulcers participated in this study. Microvascular flow and pulsatility was measured in the wound bed and in the skin surrounding the wound using laser speckle contrast imaging.
Skin-Integrated Electrogenetic Regulation of Vasculature for Accelerated Wound Healing.
Adv Sci (Weinh)
January 2025
ETH Zurich, Department of Biosystems Science and Engineering, Klingelbergstrasse 48, Basel, CH-4056, Switzerland.
Neo-vascularization plays a key role in achieving long-term viability of engineered cells contained in medical implants used in precision medicine. Moreover, strategies to promote neo-vascularization around medical implants may also be useful to promote the healing of deep wounds. In this context, a biocompatible, electroconductive borophene-poly(ε-caprolactone) (PCL) 3D platform is developed, which is called VOLT, to support designer cells engineered with a direct-current (DC) voltage-controlled gene circuit that drives secretion of vascular endothelial growth factor A (VEGFA).
View Article and Find Full Text PDFFlexible Triboelectric Nanogenerator Patch for Accelerated Wound Healing Through the Synergy of Electrostimulation and Photothermal Effect.
Small
January 2025
Guangzhou Institute of Blue Energy, Knowledge City, Huangpu District, Guangzhou, 510555, P. R. China.
Physiological wound healing process can restore the functional and structural integrity of skin, but is often delayed due to external disturbance. The development of methods for promoting the repair process of skin wounds represents a highly desired and challenging goal. Here, a flexible, self-powered, and multifunctional triboelectric nanogenerator (TENG) wound patch (e-patch) is presented for accelerating wound healing through the synergy of electrostimulation and photothermal effect.
View Article and Find Full Text PDFElectro-responsive hyaluronic acid-based click-hydrogels for wound healing.
Carbohydr Polym
January 2025
IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/ Eduard Maristany, 10-14, 08019 Barcelona, Spain; Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, 08930 Barcelona, Spain. Electronic address:
Article Synopsis
- Researchers developed a new type of hydrogel made from hyaluronic acid and a conductive polymer to help heal challenging skin wounds.
- The addition of the conductive polymer not only increased the porosity and mechanical strength of the hydrogel but also significantly boosted its electrochemical activity.
- Tests showed that the hydrogel is biocompatible and can enhance cell migration, effectively closing wounds in about 1 hour when stimulated with a small electric voltage.
Sensorable zwitterionic antibacterial hydrogel for wound electrostimulation therapy.
Biomaterials
April 2025
Key Laboratory of Biorheological Science and Technology, Chongqing University, Chongqing, 400044, China. Electronic address:
Wound healing process has always been a focal point of concern, with a plethora of hydrogel dressings available; however, their therapeutic efficacy remains a hindrance to wound closure. This article reports on a dual-network conductive system, PEDOT:PSS-co-PSBMA/XLG (PPSX) hydrogel dressing, Constructed using poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT: PSS) in combination with zwitterionic N, N-dimethyl-N-(2-methacryloyloxyethyl)-N- (3-sulfopropyl) ammonium betaine (SBMA) and nanoclay-synthesized lithium magnesium silicate (XLG). The hydrogel powder produced from it can absorb interfacial water within 30 s via physical interactions to spontaneously form hydrogels of arbitrary shapes.
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