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Solitary eyelid neurofibroma is a rare condition, and there have been no reported cases of solitary eyelid neurofibroma involving the proximal lacrimal drainage system. A 6-year-old male presented with recurrent painless swelling in the medial part of the left lower eyelid. The patient was misdiagnosed as eyelid polyp and underwent excision biopsy twice elsewhere.
View Article and Find Full Text PDFSingle-cell and spatial transcriptomics identify COL6A3 as a prognostic biomarker in undifferentiated pleomorphic sarcoma.
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Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Undifferentiated pleomorphic sarcoma (UPS) and related tumors are the most common type of soft tissue sarcoma. However, this spectrum of tumors has different etiologies with varying rates of metastasis and survival. Two dermal-based neoplasms in this class of pleomorphic sarcomas, atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS), are challenging to differentiate at initial biopsy but vary significantly in prognosis.
View Article and Find Full Text PDFBioinformatic and clinical experimental assay uncovers resistance and susceptibility mechanisms of human glioblastomas to temozolomide and identifies new combined and individual survival biomarkers outperforming promoter methylation.
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I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia.
Background: Glioblastoma (GBM) is the most aggressive and lethal central nervous system (CNS) tumor. The treatment strategy is mainly surgery and/or radiation therapy, both combined with adjuvant temozolomide (TMZ) chemotherapy. Historically, methylation of gene promoter is used as the major biomarker predicting individual tumor response to TMZ.
View Article and Find Full Text PDFBZW2 is a potential regulator of non-small cell lung cancer progression.
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Department of Cardiovascular Thoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China. Electronic address:
Background: Personalized targeted therapy has become an important strategy for cancer treatment owing to its remarkable therapeutic efficacy and safety. However, drug resistance remains the primary cause of treatment failure. Basic leucine zipper and W2 domain 2 (BZW2), which is aberrantly expressed in cancer, has been implicated in tumor progression and may serve as a new therapeutic target.
View Article and Find Full Text PDFSingle-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing.
Hum Reprod
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Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.
Study Question: What is the molecular landscape underlying the functional decline of human testicular ageing?
Summary Answer: The present study provides a comprehensive single-cell transcriptomic atlas of testes from young and old humans and offers insights into the molecular mechanisms and potential targets for human testicular ageing.
What Is Known Already: Testicular ageing is known to cause male age-related fertility decline and hypogonadism. Dysfunction of testicular cells has been considered as a key factor for testicular ageing.
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