We have developed an in vitro model of spreading depression (SD) in rat neocortex. KCl application induced a propagating wave of SD associated with a change of optical lucency and an extracellular negative wave. Both of these were abolished by aminophosphonovaleric acid (100 microM), indicating SD's mediation by NMDA receptors. SD abolished synaptically-mediated field potentials in layer II and this depression was followed by a previously undescribed, sustained LTP-like enhancement of transmission.
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| http://dx.doi.org/10.1016/s0006-8993(97)01359-0 | DOI Listing |
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