The pancreatic antioxidant system and the effect of the pretreatment with 500 mg/ kg b.w. i.p. nicotinamide were studied in male mice (CBA/J x C57BL/6J)F1 with low-dose streptozotocin-induced diabetes (50 mg/kg b.w. x 5 days). Nicotinamide prevented the development of basal hyperglycaemia, hypoinsulinemia and the growth of superoxide dismutase activity without any impact on the elevated glutathione peroxidase activity and the increase in lipid hydroperoxide level.
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