Oxidative modification of monoamine oxidases (MAO) accompanied by alteration of their substrate specificity and sensitivity to specific inhibitors was discovered by Professor V.Z. Gorkin more than 30 years ago. The mechanism of this phenomenon includes oxidation of SH groups of the enzyme. Oxidative modification of MAO is also accompanied by increased sensitivity to limited proreolysis. Modification of MAO was found in many pathological states, however, elucidation of biological role of this phenomenon requires further investigations.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
modification monoamine
8
oxidative modification
8
mao accompanied
8
modification mao
8
[oxidative modification
4
monoamine oxidase]
4
oxidase] oxidative
4
monoamine oxidases
4
oxidases mao
4
accompanied alteration
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!