The studies reported here were directed toward ascertaining in a variety of organisms whether or not any of the three lobes of the pituitary gland affected thyroid activity. We documented a thyroid stimulating action of the anterior lobe of the pituitary gland extract that was not shared in by either the intermediate or posterior lobes. Pilocarpine first depressed the stimulating action of the pituitary extract but, after the fifth injection, it accentuated the response of the thyroid gland to the pituitary extract.
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