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Charcot neuroarthropathy: Surgical and conservative treatment approaches.
Semin Vasc Surg
March 2025
Keck School of Medicine, University of Southern California, Los Angeles, CA.
Charcot neuroarthropathy (CN) is an inflammatory condition affecting the joints of patients with peripheral neuropathy; its prevalence is as high as 7.5%. It is commonly seen in patients with diabetes and poses a significant public health burden.
View Article and Find Full Text PDFHaemophagocytic lymphohistiocytosis (HLH) is a condition of uncontrolled immune activation caused by genetic defects or triggered by infections, malignancies, autoimmune diseases, drugs, pregnancy or post-transplant immunosuppression. This case describes a young man presenting with clinical jaundice and abnormal blood tests, including raised inflammatory markers, abnormal liver function, low haemoglobin (65 g/L) and a low white blood cell count (3.08×10/L).
View Article and Find Full Text PDFToxic effects of combined exposure to carbamazepine and triclosan on adult zebrafish (Danio rerio): Insights into acute mortality, neurotransmitters, biochemical response, and histopathology.
Comp Biochem Physiol C Toxicol Pharmacol
March 2025
Hydrology Center of Jining City, Jining 272100, China.
As two representative pharmaceuticals and personal care products (PCPPs), carbamazepine (CBZ) and triclosan (TCS) are frequently detected in aquatic ecosystems worldwide, but their toxicological interactions remain unclear. This work evaluated the combined toxicity of CBZ and TCS to zebrafish (Danio rerio) in terms of acute mortality, biochemical response, and histopathology. The results showed that the 96-h acute toxicity interaction of CBZ and TCS fitted well to the concentration addition (CA) model, suggesting an additive effect.
View Article and Find Full Text PDFThe potential effective components from Danlou tablet attenuates acute myocardial infarction by restoring ALOX12-mediated perturbed oxylipins.
J Ethnopharmacol
March 2025
Department of Pharmacy, Henan Province Engineering Research Center of Application & Translation of Precision Clinical Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address:
Ethnopharmacological Relevance: Danlou Tablet (DLP) was developed from the "Gualou-Xiebai-Baijiu decoction", as documented in the "Synopsis of the Golden Chamber" by Dr. Zhongjing Zhang. It is widely used for clinical treatment of different degrees of coronary heart disease (CHD).
View Article and Find Full Text PDFMultiple omics-based machine learning reveals specific macrophage sub-clusters in renal ischemia-reperfusion injury and constructs predictive models for transplant outcomes.
Comput Biol Chem
March 2025
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Institute of Urology, Capital Medical University, Beijing, China. Electronic address:
Background: Ischemia-reperfusion injury (IRI) is closely associated with numerous severe postoperative complications, including acute rejection, delayed graft function (DGF) and graft failure. Macrophages are central to modulating the aseptic inflammatory response during the IRI process. The objective of this study is to conduct an analysis of the developmental and differentiation characteristics of macrophages in IRI, identify distinct molecules subtypes of IRI, and establish robust predictive strategies for DGF and graft survival.
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