Dose-response curves for the effect of continuous infusion of histamine on gastric acid secretion were obtained in 10 patients with iron deficiency anemia due to hookworm infection. Each patient was studied with 4 doses (40, 60, 80 and 100 mug/kg/h) of histamine acid phosphate administered for 3 h, on separate days, in random fashion. The acid output increased with the dose of histamine, the maximal acid output was reached in all patients at the dose of 100 mug/kg/h. The dose of histamine when calculated according to body weight correlated well with the maximal acid output; the absolute dose of histamine had no correlation with the maximal acid response. The dose-response curve of stimulated acid output in anemia patients was much flatter than in control patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000197918 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prokineticin 2 protein is diurnally expressed in PER2 containing clock neurons in the mouse suprachiasmatic nucleus.
Peptides
January 2025
Department of Clinical Biochemistry, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Expression of prokineticin 2 (PK2) mRNA in the suprachiasmatic nucleus (SCN), also knowns as the brain's clock, exhibits circadian oscillations with peak levels midday, zeitgeber time (ZT) 4, and almost undetectable levels during night. This circadian expression profile has substantially contributed to the suggested role of PK2 as an SCN output molecule involved in transmitting circadian rhythm of behavior and physiology. Due to unreliable specificity of PK2 antibodies, the 81 amino acid protein has primarily been studied at the mRNA level and correlation between circadian oscillating mRNAs and protein products are infrequent.
View Article and Find Full Text PDFDeep eutectic solvent-based green extraction of Strychnos potatorum seed phenolics: Process optimization via response surface methodology and artificial neural network.
Talanta
December 2024
Department of Chemistry, Government College University, Lahore, Pakistan. Electronic address:
The current research focused on extraction optimization of bioactive compounds from Strychnos potatorum seeds (SPs) using an eco-friendly glycerol-sodium acetate based deep eutectic solvent (DES). The optimization was accomplished using response surface methodology (RSM) and artificial neural networking (ANN). The independent variables included shaking time (A), temperature (B), and solvent-to-feed ratio (C), and the responses were the extraction yield, total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity (DPPH), and antidiabetic activity (α-amylase inhibitory activity).
View Article and Find Full Text PDFLeveraging Synthetic Antibody-DNA Conjugates to Expand the CRISPR-Cas12a Biosensing Toolbox.
ACS Synth Biol
January 2025
Department of Chemical Science and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy.
We report here the use of antibody-DNA conjugates (Ab-DNA) to activate the collateral cleavage activity of the CRISPR-Cas12a enzyme. Our findings demonstrate that Ab-DNA conjugates effectively trigger the collateral cleavage activity of CRISPR-Cas12a, enabling the transduction of antibody-mediated recognition events into fluorescence outputs. We developed two different immunoassays using an Ab-DNA as activator of Cas12a: the CRISPR-based immunosensing assay (CIA) for detecting SARS-CoV-2 spike S protein, which shows superior sensitivity compared with the traditional enzyme-linked immunosorbent assay (ELISA), and the CRISPR-based immunomagnetic assay (CIMA).
View Article and Find Full Text PDFKonjac Glucomannan and Its Degradation Products Inhibit Intestinal Lipid Absorption by Regulating Gut Microbiota and the Production of Short-Chain Fatty Acids.
J Agric Food Chem
January 2025
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Article Synopsis
- KGM (konjac glucomannan) significantly reduces blood lipids and intestinal lipid accumulation in obese mice compared to its degradation product DKGM.
- KGM effects include downregulation of certain intestinal genes linked to lipid absorption and more effective inhibition of fatty acid uptake in tissues outside the intestines.
- The study highlights KGM's role in enhancing the intestinal barrier and influencing gut microbiota, suggesting that its mechanism relates to viscosity, HDAC3 activity, and how microbes interact with dietary fiber to affect energy balance.
G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells.
Sci Transl Med
January 2025
Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Elevated glucagon concentrations have been reported in patients with type 2 diabetes (T2D). A critical role for α cell-intrinsic mechanisms in regulating glucagon secretion was previously established through genetic manipulation of the glycolytic enzyme glucokinase (GCK) in mice. Genetic variation at the glucose-6-phosphatase catalytic subunit 2 () locus, encoding an enzyme that opposes GCK, has been reproducibly associated with fasting blood glucose and hemoglobin A1c.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!