Purpose: The aim of our study was to evaluate a new fluorocarbon (Teflon AF), used as a coating of poly-methylmethacrylate intraocular lenses. Teflon AF can be dissolved in special solvents (liquid fluorocarbons). It is the first amorphous and transparent form of teflon.
Materials And Methods: The coating was performed and the surface quality of the teflon-coated lenses was evaluated by scanning electron microscopy. Twenty teflon-coated and 10 uncoated lenses were implanted in rabbit eyes after phacoemulsification. They were compared concerning the presence of iris-lens synechias and the number of deposits on the lens' surfaces. An in vitro static touch model was used to compare endothelial damage produced by the 2 kinds of intraocular lenses. The results from this model were quantitatively analyzed, using the BIOCOM 200 image-processing system.
Results: The teflon group had no iris-lens synechias and the control group had 2 extensive synechias. There were significantly fewer deposits on the surfaces of teflon-coated lenses on days 30 and 60 post-operatively (P < 0.0001) than on the control lenses. Teflon-coated lenses produced significantly less endothelial damage than did control lenses (P < 0.0001).
Conclusions: Teflon AF presents an anti-adhesive effect that increases the biocompatibility of polymethylmethacrylate lenses and reduces endothelial damage during their intraocular insertion.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Versatile Miniature Tunable Liquid Lenses Using Transparent Graphene Electrodes.
Langmuir
February 2016
Department of Electrical and Computer Engineering and ‡Department of Physics and Astronomy, Wayne State University, Detroit, Michigan 48202, United States.
This paper presents, for the first time, versatile and low-cost miniature liquid lenses with graphene as electrodes. Tunable focal length is achieved by changing the droplet curvature using electrowetting on dielectric (EWOD). Ionic liquid and KCl solution are utilized as lens liquid on the top of a flexible Teflon-coated PDMS/parylene membrane.
View Article and Find Full Text PDFNeutral red assay of the cytotoxicity of fluorocarbon-coated polymethylmethacrylate intraocular lenses in vitro.
J Biomed Mater Res
February 2000
Department of Ophthalmology, Hôtel-Dieu Hospital, and Laboratoire de Recherche sur les Therapeutiques Substitutives en Ophtalmologie (EA 2395, CRI 9808), 1, place du Parvis-Notre-Dame, F-75181, Paris Cedex 04, France.
Polymethylmethacrylate (PMMA) intraocular lenses (IOLs) were coated with Teflon AF, an amorphous, transparent Teflon, to render them highly hydrophobic. Teflon-coated PMMA IOLs were immersed in culture medium for 30 days at 37 degrees C. Four concentrations of the IOL leachables, 2 concentrations of a toxic control (phenol), and complete liquid culture medium (nontoxic control) were incubated for 24 h in a 96-well plate containing confluent L-929 fibroblasts.
View Article and Find Full Text PDFEvaluation of teflon-coated intraocular lenses in an organ culture method.
J Biomed Mater Res
September 1999
Department of Ophthalmology, Hôtel-Dieu Hospital, and Laboratoire de Recherche sur les Therapeutiques Substitutives en Ophtalmologie (EA 2395, CRI 9808), 1, place du Parvis-Notre-Dame, F-75181, Paris Cedex 04, France.
An amorphous and transparent form of Teflon is proposed as a coating of polymethylmethacrylate (PMMA) intraocular lenses (IOLs), rendering them highly hydrophobic. We used an organ culture method to evaluate cell adhesion, proliferation, and migration on Teflon-coated IOLs. Corneal explants from 14-day-old chicken embryos were placed on a semisolid culture medium and covered with uncoated PMMA (n = 36) and Teflon-coated PMMA (n = 36) IOLs and two controls, Thermanox (n = 84) and latex (n = 36).
View Article and Find Full Text PDFIn vivo study of a fluorocarbon polymer-coated intraocular lens in a rabbit model.
J Cataract Refract Surg
March 1998
Hôtel-Dieu Hopital, Paris, France.
Purpose: To evaluate the biocompatibility in rabbit eyes of poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) that were surface modified using Teflon AF.
Setting: Hôtel-Dieu Hospital, Paris Cedex, France.
Methods: The IOLs were coated with Teflon AF, an amorphous, transparent, and highly hydrophobic fluorocarbon polymer, by immersing them in Teflon AF 5% and evaporating the solvent (C8F18).
Endothelial damage caused by uncoated and fluorocarbon-coated poly(methyl methacrylate) intraocular lenses.
J Cataract Refract Surg
September 1997
French Medical Institute for Health, Paris, France.
Purpose: To assess endothelial damage induced by poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) coated with a fluorocarbon polymer, Teflon AF, to make them highly hydrophobic.
Setting: Department of Ophthalmology. Hôtel-Dieu Hospital, Paris, France.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!