AI Article Synopsis
- The secretion of growth hormone (GH) in rodents differs by sex and influences hepatic gene expression.
- Researchers cloned the glycine N-methyltransferase (GNMT) cDNA in mice and found its mRNA levels are significantly lower in male livers compared to females.
- When male mice were hypophysectomized, their GNMT expression increased to female levels, but administering GH to these males reduced expression, highlighting that GH secretion patterns regulate this sex difference in GNMT expression.
Article Abstract
The secretion pattern of putuitary growth hormone (GH) in rodents is sexually dimorphic and regulates the expression of some hepatic genes. We report cloning of mouse glycine N-methyltransferase (GNMT) cDNA. The mouse GNMT mRNA is expressed at much lower levels in male than in female livers. Hypophysectomy in male mice resulted in as a high level of the expression as in female mice. Treatment with GH of hypophysectomized male mice twice a day for 5 days decreased the expression. These results indicate that the sex difference of the mouse GNMT expression is regulated by GH secretion patterns.
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| http://dx.doi.org/10.1055/s-2007-978982 | DOI Listing |
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