As a member of the phylum Microspora, Nosema algerae is a small obligate intracellular parasite. Its free invasive stage is a spore with a characteristic cellular organization, including an apically anchored polar tube that serves as a tool for the transmission of genetic material into the host cell. By detailed electron micrographic documentation of the spore ultrastructure we present the aspects related to the biologic process of spore extrusion. Our ultrastructure findings confirm that the extrusion process of microsporidian spores is based on extreme changes in their organization. This study is the first complete ultrastructural documentation of N. algerae concerning the extrusion process, which can be subdivided into different stages: the breakdown of the microsporidian cellular compartmentation; the filling of a preformed polar tube with modified sporoplasm; the uncoiling of the polar tube, which in this stage has reached its final length; and, finally, its extrusion and screw-like movement.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s004360050368 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
NcSWP8, a New Spore Wall Protein, Interacts with Polar Tube Proteins in the Parasitic Microsporidia .
Microorganisms
January 2025
Key Laboratory of Pollinator Resources Conservation and Utilization of the Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing Normal University, Chongqing 401331, China.
is a pathogen that affects and Fabricius, capable of spreading within and between honeybee colonies. The spore wall of microsporidia is the initial structure to contact the host cell directly, which may play a crucial role in the infection process. Currently, several spore wall proteins have been identified in microsporidia, but only two spore wall proteins from have been characterized.
View Article and Find Full Text PDFExtracellular vesicle-associated miR-ERIA exerts the anti-angiogenic effect of macrophages in diabetic wound healing.
Diabetes
January 2025
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Many cell types are involved in the regulation of cutaneous wound healing in diabetes. Clarifying the mechanism of cell-cell interactions is important for identifying therapeutic targets for diabetic cutaneous ulcers. The function of vascular endothelial cells in the cutaneous microenvironment is critical, and a decrease in their biological function leads directly to refractory wound healing.
View Article and Find Full Text PDFMatrix interactions regulate epithelial polarity and cohesion in the second heart field.
Dev Cell
January 2025
Aix-Marseille Université, CNRS UMR 7288, IBDM, Marseille, France. Electronic address:
Addition of epithelial progenitor cells drives progressive extension of the heart tube during cardiac morphogenesis. In this issue of Developmental Cell, Arriagada et al. (2024) refine our understanding of how these cells condition and interact with the underlying extracellular matrix, demonstrating that autonomous fibronectin synthesis controls their apicobasal polarity and deployment to the heart.
View Article and Find Full Text PDFCryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1.
Nat Commun
January 2025
Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along the epithelial plane perpendicular to the apical-basal direction, which is important for tissue morphogenesis, development and collective cell behavior. Mutations in Vangl are associated with developmental defects, including neural tube defects (NTDs), according to human cohort studies of sporadic and familial cases. The complex mechanisms underlying Vangl-mediated PCP signaling or Vangl-associated human congenital diseases have been hampered by the lack of molecular characterizations of Vangl.
View Article and Find Full Text PDFManipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro-Angiogenic Macrophage Polarization via Activation of the PI3K-Akt Signaling Pathway.
Adv Sci (Weinh)
December 2024
Department of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Regulation of the immune response is key to promoting bone regeneration by electroactive biomaterials. However, how electrical signals at the micro- and nanoscale regulate the immune response and subsequent angiogenesis during bone regeneration remains to be elucidated. Here, the distinctly different surface potential distributions on charged poly(vinylidene fluoridetrifluoroethylene) (P(VDF-TrFE)) matrix surfaces are established by altering the dimensions of ferroelectric nanofillers from 0D BaTiO nanoparticles (homogeneous surface potential distribution, HOPD) to 1D BaTiO nanofibers (heterogeneous surface potential distribution, HEPD).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!