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Caffeine intake during gestation and lactation causes long-term behavioral impairments in heterogenic mice offspring in a sex-dependent manner.
Pharmacol Biochem Behav
December 2024
Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:
Growing evidence has indicated a potential association between maternal consumption of caffeine and impaired cognition and behavior in rodent offspring. However, potential sex differences, as well as caffeine-related effects in subsequent generations are still poorly investigated. We aimed to investigate the impact of pre-and/or neonatal exposition to caffeine on the neurodevelopment of male and female mice offspring.
View Article and Find Full Text PDFCase Report of an Urgent Determination of Malignant Hyperthermia Status of a 24-Week Pregnant Patient Requiring Intrauterine Fetal Surgery.
A A Pract
December 2024
From the Department of Anesthesiology, Uniformed Services University, Bethesda, Maryland.
Malignant hyperthermia (MH) is a potentially fatal disorder triggered by volatile anesthetics or succinylcholine, inducing a hypermetabolic crisis in susceptible patients. The caffeine-halothane contracture test (CHCT) remains a gold standard for MH detection. The authors describe a pregnant patient with a history of exertional rhabdomyolysis, who required urgent MH screening for administration of MH-triggering anesthetics.
View Article and Find Full Text PDFPerinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.
Stroke
November 2024
Department of Pediatrics (J.K.M., Y.W., J.H., A.I., C.H., R.S.H., C.V., H.M., J.L.-B., J.R.F., D.M.F., E.M.), University of California San Francisco.
Article Synopsis
- Neonatal hypoxic-ischemic encephalopathy primarily impacts low- and middle-income countries, with therapeutic hypothermia often proving ineffective, highlighting a need for earlier treatment strategies.
- A study involved administering perinatal caffeine to near-term lambs undergoing severe hypoxia-ischemia, assessing its pharmacokinetics, safety, and efficacy in improving outcomes.
- Caffeine administration enhanced neurodevelopmental results and decreased inflammation and gray matter damage, suggesting it could be a viable treatment for affected neonates compared to previous studies on other medications.
Modelling the maternal-fetal interface: An in vitro approach to investigate nutrient and drug transport across the human placenta.
J Cell Mol Med
October 2024
Institute of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Bern, Bern, Switzerland.
The placenta plays a critical role in maternal-fetal nutrient transport and fetal protection against drugs. Creating physiological in vitro models to study these processes is crucial, but technically challenging. This study introduces an efficient cell model that mimics the human placental barrier using co-cultures of primary trophoblasts and primary human umbilical vein endothelial cells (HUVEC) on a Transwell-based system.
View Article and Find Full Text PDFMendelian randomization analysis of maternal coffee consumption during pregnancy on offspring neurodevelopmental difficulties in the Norwegian Mother, Father and Child Cohort Study (MoBa).
Psychol Med
October 2024
MRC (Medical Research Council) Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Article Synopsis
- Some studies have suggested that drinking coffee during pregnancy might affect how kids develop, but the results have been mixed.
- This study looked at the link between mothers' and fathers' coffee consumption before and during pregnancy, and how it relates to children's development issues.
- The findings showed a connection between moms who drank coffee and some behavioral challenges in kids, but when factors like smoking and education were considered, the link became weaker.
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