Background: Apnoeic events are often accompanied by various disturbances in electric cardiac activity, the character and development as well as mechanism of which remain broadly unknown suggesting both direct metabolic defects as well as neurogenous autonomic influences.
Methods: Changes in ECG and heart rate induced by repeated short-lasting inhalation of hypoxic poikilocapnic mixtures (100% N2 and/or 0.5-1% CO2 or 6% CO2 in N2) were analyzed in 17 spontaneously breathing cats anaesthetized with sodium pentobarbitone (40 mg.kg-1i.p.).
Results: N2 inhalation evokes hypoxaemic hyperventilation progressing into apnoea and bradycardia with secondary low-level atrioventricular conduction block and ischaemic changes in ECG. Contrary to this reversible respiratory failure, hypoxaemic hypercapnic hyperventilation and apnoea evoked by inhalation of 6% CO2 in N2 or 100% CO2 were accompanied by very marked additional effects of hypercapnia and acidosis. They appeared earlier and were more severe (high-level AV conduction block and premature contractions) suggesting direct myocardial alteration due to acidosis.
Conclusions: The results provide experimental data for better understanding the dynamics, intensity and development of dysrhythmias and ECG changes occurring in two different types of cardiorespiratory failure in animal experiments as well as in central and obstructive types of sleep apnoea and other apnoeic events in humans. (Fig. 3, Ref. 27.)
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Int J Environ Res Public Health
January 2025
Study Design and Scientific Writing Laboratory, Centro Universitario FMABC, Santo André 09060-870, SP, Brazil.
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January 2025
Department of Pharmacology, Shantou University Medical College, Shantou, Guangdong, China.
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Sports (Basel)
January 2025
Exercise and Sport Sciences Department, Metropolitan State University of Denver, Denver, CO 80204, USA.
Background: High-intensity endurance training induces specific cardiac adaptations, often observed through electrocardiographic (ECG) changes. This study investigated the prevalence of ECG abnormalities in national-level Australian triathletes compared to sedentary controls.
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Cureus
December 2024
Respiratory Medicine, Gujarat Medical Education and Research Society of Department of Health and Family Welfare (GMERS) Medical College and General Hospital, Vadodara, IND.
Background Community-acquired bacterial pneumonia (CABP) is associated with a substantial healthcare burden. The emergence of multi-drug resistance in is becoming an increasing concern in the management of CABP. This study aims to evaluate the efficacy and safety of levonadifloxacin in the treatment of CABP, focusing on both oral and intravenous (IV) therapy.
View Article and Find Full Text PDFFood Res Int
February 2025
Antioxidant Polyphenols Team, Department of Food Engineering, Sichuan University, Chengdu 610065, PR China; The Key Laboratory of Food Science and Technology of Sichuan Province of Education, Sichuan University, Chengdu 610065, PR China. Electronic address:
Effects of catechins with different structure characteristics on the structure and properties of gluten-catechin covalent complex were investigated, and the structure-activity relationship was further explored. Catechins including epicatechin (EC), epigallocatechin (EGC), epicatechin-3-gallate (ECG), and epigallocatechin-3-gallate (EGCG) could successfully covalently bind with gluten through C-N and/or C-S bonds. The physicochemical properties of covalent complex, including particle size, thermal stability, content of free amino groups, free sulfhydryl groups and disulfide bonds, were significantly affected by different catechins, and the action order was: EGCG > ECG > EGC > EC.
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