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Effects of manual acupuncture combined with donepezil in a mouse model of Alzheimer's disease.
Acupunct Med
February 2019
1 Beijing University of Chinese Medicine, Beijing, China.
Objectives: To explore whether combined therapy with donepezil and acupuncture is better than treatment with donepezil or acupuncture individually in a rat model of Alzheimer's disease.
Methods: In this study, we randomly divided 40 7.5-month-old senescence-accelerated mouse prone 8 (SAMP8) male mice into four groups: SAMP8, SAMP8+D, SAMP8+MA and SAMP8+D+MA.
Exploring the Phase Behavior of Monoolein/Oleic Acid/Water Systems for Enhanced Donezepil Administration for Alzheimer Disease Treatment.
J Pharm Sci
January 2016
Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Unifal-MG, Alfenas, Minas Gerais, Brazil.
Donepezil is a drug usually administered by oral route for Alzheimer disease treatment, but several gastric side effects have been reported as diarrhea, nausea, and anorexia. We explored the phase behavior of lyotropic liquid crystalline (LLC) mesophases composed by monoolein/oleic acid/water for enhanced administration of donepezil. Polarized light microscopy suggested that these systems ranged from isotropic inverse micellar solutions (L2) to viscous and birefringent reverse hexagonal (HII) mesophases according to the amount of water in the ternary systems.
View Article and Find Full Text PDFThe influence of cholinesterase inhibitor therapy for dementia on risk of cardiac pacemaker insertion: a retrospective, population-based, health administrative databases study in Ontario, Canada.
BMC Neurol
April 2015
Department of Epidemiology & Community Medicine, University of Ottawa; Ottawa Hospital Research Institute; ICES uOttawa, The Ottawa Hospital, ASB1-003, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada.
Background: Cholinesterase inhibitors are used to treat the symptoms of dementia and can theoretically cause bradycardia. Previous studies suggest that patients taking these medications have an increased risk of undergoing pacemaker insertion. Since these drugs have a marginal impact on patient outcomes, it might be preferable to change drug treatment rather than implant a pacemaker.
View Article and Find Full Text PDFContinuous treatment with antidementia drugs in Germany 2003-2013: a retrospective database analysis.
Int Psychogeriatr
August 2015
Epidemiology & Evidence Based Medicine,Real World Evidence Solutions,IMS Health,Frankfurt,Germany.
Background: Continuous treatment is an important indicator of medication adherence in dementia. However, long-term studies in larger clinical settings are lacking, and little is known about moderating effects of patient and service characteristics.
Methods: Data from 12,910 outpatients with dementia (mean age 79.
Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials.
Alzheimers Dement
September 2015
Alzheimer's Disease Cooperative Study, Department of Neurosciences, University of California San Diego, School of Medicine, San Diego, CA, USA. Electronic address:
Introduction: Little is known about the utility of plasma amyloid beta (Aβ) in clinical trials of Alzheimer's disease (AD).
Methods: We analyzed longitudinal plasma samples from two large multicenter clinical trials: (1) donezepil and vitamin E in mild cognitive impairment (n = 405, 24 months) and (2) simvastatin in mild to moderate AD (n = 225, 18 months).
Results: Baseline plasma Aβ was not related to cognitive or clinical progression.
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