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Fatal anabolic androgenic steroid overdose in an amateur bodybuilder: a clinical and autopsy report.
Forensic Sci Med Pathol
November 2023
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, 605006, India.
Article Synopsis
- Stanozolol is a synthetic anabolic steroid used by bodybuilders to increase muscle mass, but it can cause severe liver damage, including fatal conditions like hepatic necrosis.
- A case report details the death of a 35-year-old bodybuilder who developed jaundice and liver failure after three months of stanozolol use, confirming the drug's presence in his system during autopsy.
- The death was attributed to liver injury caused by stanozolol overdose, highlighting the urgent need for increased awareness about the risks of anabolic steroid use, especially with its rising popularity.
Histiocytoid giant cellulitis-like Sweet syndrome at the site of sternal aspiration: A case report and review of literature.
World J Clin Cases
September 2022
Department of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian 116014, Liaoning Province, China.
Background: Giant cellulitis-like Sweet syndrome (SS) is a rare subtype of SS, and reports of the combined histiocytoid type of pathology are scarce. Here, we report a case of SS with distinctive clinical presentations and which was difficult to distinguish from cellulitis. By sharing this case and a discussion of the related literature in detail, we aim to provide clinicians with new insights into the characteristics of histiocytoid giant cellulitis-like (HGC)-SS and the pathogenesis of SS.
View Article and Find Full Text PDFOrgan-on-a-chip: Determine feasibility of a human liver microphysiological model to assess long-term steroid metabolites in sports drug testing.
Drug Test Anal
November 2021
Center for Preventive Doping Research/Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.
A fundamental challenge in preventive doping research is the study of metabolic pathways of substances banned in sport. However, the pharmacological predictions obtained by conventional in vitro or in vivo animal studies are occasionally of limited transferability to humans according to an inability of in vitro models to mimic higher order system physiology or due to various species-specific differences using animal models. A more recently established technology for simulating human physiology is the "organ-on-a-chip" principle.
View Article and Find Full Text PDFSuccessful perioperative management of three patients with hereditary angioedema without C1 esterase inhibitor therapy: A developing country perspective.
Immunobiology
November 2020
Department of Clinical Immunology, University College Hospitals, London and Addenbrooke's Hospital, Cambridge, UK.
Background: Hereditary angioedema (HAE) is a rare inherited disorder characterized by sudden and unpredictable appearance of swelling. Surgical procedures, even minor ones, are known to precipitate an attack in these patients. C1 esterase inhibitor (C1-INH) therapy may be effective for short term prophylaxis in such situations.
View Article and Find Full Text PDFCompression therapy is the gold standard treatment for venous leg ulcers (VLUs); however, with adjunctive pharmacological therapies and poor patient adherence using compressive dressings, clinicians are looking to find the advantage in treating VLUs. This literature review focuses on the efficacy of pharmacological agents, quality of life using agents in addition to compression therapy, and cost effectiveness to indicate the best outcomes for pharmacological treatment of VLUs. The following available venotonic, hemorheologic, and fibrinolytic agents were reviewed for oral management in treating VLUs: pentoxifylline, flavonoids (diosmin, hidrosmin, rutosides, and micronized purified flavonoid fraction, Vasculera), Red-Vine-Leaf-Extract AS 195, Ruscus, Ginkgo biloba, Centella asiatica, Pycnogenol (French maritime pine bark), escin/horse chestnut extract, nutritional supplements (ie, zinc and magnesium, glycosaminoglycans [sulodexide], mesoglycans), Axaven, cilostazol, fibrinolytic enhancers (stanozolol and defibrotide), calcium dobesilate, aspirin, antibiotics (antimicrobials, doxycycline, levamisole), diuretics, cinnarizine, naftazone, and benzarone.
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