AI Article Synopsis
- The study focused on measuring serum levels of IGF-I, IGF-II, and their binding proteins in children aged 3 months to 2 years with nonorganic failure to thrive (NOFTT).
- The NOFTT group exhibited significantly higher levels of IGFBP-1 compared to the control group, indicating a possible connection between this binding protein and the condition.
- However, there were no significant differences in IGF-I, IGF-II, and IGFBP-3 levels between the groups, leading to the conclusion that these measures are not useful for assessing nutritional status in young children with NOFTT.
Article Abstract
The aim of our study was to determine the serum levels of IGF-I, IGF-II, and their binding proteins IGFBP-1 and IGFBP-3 in young children 3 months to 2 years of age with nonorganic failure to thrive (NOFTT). 29 children with NOFTT and 32 normal controls were recruited and studied for auxologic and hormonal parameters. The NOFTT group had significantly higher serum concentrations of IGFBP-1 than the control group: 57.7+/-18 vs. 48+/-19 microg/l (p < 0.05). IGF-I and IGF-II serum levels were highly correlated to serum IGFBP-3 but there were no differences in the serum IGF-I, IGF-II and IGFBP-3 levels between the groups. We conclude that IGF-I, IGF-II, and IGFBP-3 are not useful for the evaluation of nutritional status in children, under the age of 2 years, with NOFTT.
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