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Escalation of genome defense capacity enables control of an expanding meiotic driver.
Proc Natl Acad Sci U S A
January 2025
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
From RNA interference to chromatin silencing, diverse genome defense pathways silence selfish genetic elements to safeguard genome integrity. Despite their diversity, different defense pathways share a modular organization, where numerous specificity factors identify diverse targets and common effectors silence them. In the PIWI-interacting RNA (piRNA) pathway, target RNAs are first identified by complementary base pairing with piRNAs and then silenced by PIWI-clade nucleases.
View Article and Find Full Text PDFCentring women's voices in contraceptive innovation: building the case for an on-demand, pericoital pill.
BMJ Sex Reprod Health
January 2025
Independent Consultant, Melbourne, Victoria, Australia.
Spotlight on Mitochondrial Health: A Trailblazing Fluorescent Tool for Cancer Detection and Surgical Guidance.
Anal Chem
November 2024
College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
Mitochondria play a pivotal role in maintaining normal physiological functions. Mitochondrial autophagy, namely, mitophagy, is a selective catabolic disposal of impaired mitochondria through an autophagic mechanism during episodes of mitochondrial harm. This selective removal, e.
View Article and Find Full Text PDFProfessor John Roderick Cameron's Influence on Radiation Safety in Terrestrial and Space Environments.
J Biomed Phys Eng
June 2024
Department of Radiation Oncology, Edward Hines Jr VA Hospital, Hines, IL, United States.
Professor John Roderick Cameron (1922-2005) stands out as a trailblazer in the field of medical physics, whose innovative work has deeply influenced radiation protection and the broader medical radiation field through sound technical judgment and insight. Best known for inventing the bone densitometry device, his pioneering efforts have reshaped modern medical practices far beyond his initial breakthroughs. Cameron's explorations extended into the realms of space biomedical science and models of terrestrial radiation, areas where his insights continue to resonate today.
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