AI Article Synopsis

  • Intra-operative localization of the sensorimotor cortex helps neurosurgeons safely remove lesions near the central sulcus, and direct cortical recordings, like somatosensory evoked potentials (SEPs), assist in this process.
  • Researchers analyzed SEPs from 20 neurosurgical patients and employed a spatiotemporal dipole model to pinpoint the equivalent dipoles associated with cortical SEP distributions.
  • The study identified two distinct dipoles in the postcentral gyrus, confirming a reliable method for accurately localizing the hand sensory area in the cortex using objective dipole modeling rather than subjective visual analysis.

Article Abstract

Intra-operative localization of sensorimotor cortex is of increasing importance as neurosurgical techniques allow safe and accurate removal of lesions around the central sulcus. Although direct cortical recordings of somatosensory evoked potentials (SEPs) are known to be helpful for cortical localization, source localization models can provide more precise estimates than subjective visual analysis. In addition to intra-operative analysis of waveforms and amplitudes of SEPs to median nerve stimulation in 20 neurosurgical patients, we used a spatiotemporal dipole model to determine the location of the equivalent dipoles consistent with the cortical distribution of the SEPs. The early cortical SEPs were modeled by 2 equivalent dipoles located in the postcentral gyrus. The first dipole was primarily tangentially oriented and explained N20 and P20 peaks. The second dipole was primarily radially oriented and explained P25 activity. We found consistent localization of the first dipole in the postcentral gyrus, which was always located within 8 mm of the central sulcus, with an average distance of 3 mm. This finding provides an objective basis for using the SEP phase reversal method for cortical localization. We conclude that dipole source modeling of the cortical SEPs can be considered as an objective way of localizing the cortical hand sensory area.

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Source
http://dx.doi.org/10.1007/BF01410971DOI Listing

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