Background: Advanced carcinoma of the gallbladder typically is unresponsive to chemotherapy, and patients with progressive metastatic disease have a short survival.
Methods: A patient with advanced metastatic carcinoma of the gallbladder causing peritoneal carcinomatosis and hepatic metastases is reported. This patient achieved a dramatic remission with gemcitabine after failing two other chemotherapeutic regimens.
Results: Response included reversal of complete small bowel obstruction with resumption of the ability to eat and the disappearance of liver metastases.
Conclusions: Gemcitabine appears to be worthy of organized clinical trials in patients with this notoriously chemotherapy-resistant malignancy.
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Background Incidental gallbladder carcinoma (IGBC) remains a significant clinical challenge, with its diagnosis often delayed due to the asymptomatic nature of the disease and its incidental discovery post-cholecystectomy. This study's aim is to calculate incidence in a high-risk, region-specific (North Indian) population and also to provide novel insights into clinical presentation as well as macroscopic and histopathological features of IGBC. Material and methods This retrospective observational study spanned four years (August 2013 to July 2016) and included a total of 3096 cases.
View Article and Find Full Text PDFExamination of Gallbladders at Military Treatment Facilities: Is Histologic Analysis Necessary?
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January 2025
Department of Pathology and Area Laboratory Services, Brooke Army Medical Center, San Antonio, TX 78234, USA.
Introduction: Gallbladder specimens from cholecystectomy procedures are a common specimen evaluated by military pathologists. These are often removed for inflammatory causes. Previous studies show that the incidence of gallbladder carcinoma (GBC) is around 3%.
View Article and Find Full Text PDFTumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis.
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Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, China.
Purpose: This study aimed to investigate whether tumor-associated lymphatic vessel density (LVD) could predict the survival of patients with hepato-biliary-pancreatic (HBP) cancers after radical resection.
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Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:
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Department of Medical College, Jinan University, Guangzhou 510000, Guangdong Province, China.
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