The relationship between visual acuity assessed by the ophthalmologist and functional visual disorders evaluated by the patient himself by means of special tests is an important indicator of successful cataract operations. At present for this purpose four tests are used: VF 14, CSS, evaluation of problems of vision, evaluation of satisfaction with vision. The use of the above tests under local conditions was tested in a small group of 60 patients, 43 (72%) being women. One third of the patients had cataracts of both eyes operated. 20% of the patients suffered from the dry from of age related macular degeneration of the fundus before operation. These patients suffered after surgery from poorer near vision and a poorer resulting corrected far vision. The results of the trial provided evidence that the patients are indicated for surgery of the second eye when vision is better and the subjective complaints are smaller, in order to restore rapidly binocular vision. This corresponds with higher values of the VF index after surgery of both eyes. In patients with age related macular degeneration there is a markedly reduced value of the VF index after surgery, while the CSS before surgery is the same as in patients with a normal finding. This test cannot be used for accurate evaluation of the part played by age related macular degeneration and cataract in the deterioration of visual functions.
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JAMA Netw Open
January 2025
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Importance: Determining spectacle-corrected visual acuity (VA) is essential when managing many ophthalmic diseases. If artificial intelligence (AI) evaluations of macular images estimated this VA from a fundus image, AI might provide spectacle-corrected VA without technician costs, reduce visit time, or facilitate home monitoring of VA from fundus images obtained outside of the clinic.
Objective: To estimate spectacle-corrected VA measured on a standard eye chart among patients with diabetic macular edema (DME) in clinical practice settings using previously validated AI algorithms evaluating best-corrected VA from fundus photographs in eyes with DME.
Invest Ophthalmol Vis Sci
January 2025
University of Bordeaux, INSERM U1219, BPH, Bordeaux, France.
Invest Ophthalmol Vis Sci
January 2025
UCL Institute of Ophthalmology, University College London, London, United Kingdom.
Purpose: The purpose of this study was to analyze the retinal sensitivity under photopic, mesopic, and scotopic conditions in a cohort of patients affected with KCNV2-associated retinopathy.
Methods: Cross-sectional evaluation of molecularly confirmed individuals was conducted. Data were obtained prospectively.
Transl Vis Sci Technol
January 2025
Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Purpose: Alteration of visual acuity in wet age-related macular degeneration (AMD) is mostly driven by vascular endothelial growth factor A (VEGF-A)-induced edema from leaky newly forming blood vessels below the retina layers. To date, all therapies aimed at alleviation of this process have relied on inhibition of VEGF-A activity. Although effective in preventing vascular leak and edema, this approach also leads to the loss of normal vasculature and multiple related side effects.
View Article and Find Full Text PDFTransl Vis Sci Technol
January 2025
FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Purpose: Geographic atrophy (GA), an advanced form of dry age-related macular degeneration (AMD), has limited treatment options. This study introduces a novel mouse model featuring an expanding GA patch that can be used to test mechanisms and therapeutics.
Methods: C57Bl/6J male mice (n = 96) aged 9-10 weeks received an intraperitoneal (IP) injection of 20 mg/kg sodium iodate (NaIO3).
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