Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0162-3109(97)00087-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recurrent meningococcal infections as a sign of inborn error immunity.
Epidemiol Mikrobiol Imunol
December 2024
Invasive meningococcal diseases (IMD) caused by Neisseria meningitidis are generally rare. They affect mostly selected age categories and risk groups of patients (in terms of age, comorbidities, or applied therapy), and the immune system and its defects may play an important modifying role. Meningococcal infections could be the first and only clinical sign of unrecognised immunodeficiency.
View Article and Find Full Text PDFPlasma-based proteomic and metabolomic characterization of lung and lymph node metastases in cervical cancer patients.
J Pharm Biomed Anal
January 2025
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China; Key Laboratory for Molecular Medicine and Chinese Medicine Preparations, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China. Electronic address:
Article Synopsis
- - Metastasis is a major concern in cervical cancer (CC), particularly affecting lymph nodes and lungs, leading to poor patient outcomes and limited predictive tools for determining metastasis risk.
- - The study analyzed plasma samples from CC patients with and without metastasis using advanced proteomics and metabolomics techniques, revealing common inflammatory processes and distinct metabolic changes between lung and lymph node metastasis groups.
- - Researchers identified two promising biomarker panels for predicting lung and lymph node metastasis, demonstrating strong diagnostic potential with high accuracy in both training and testing sets.
Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration.
MAbs
October 2024
Research and Product Development, Alexion, AstraZeneca Rare Disease, New Haven, CT, USA.
Article Synopsis
- Tarperprumig (ALXN1820) is a bispecific antibody designed to treat conditions caused by dysregulated activity in the complement alternative pathway, usable via small volume injections either under the skin or intravenously.
- It consists of two variable domains that target properdin and human serum albumin, showing a high binding affinity and forming a stable complex.
- The antibody effectively inhibits key processes related to complement pathway activation and is currently undergoing clinical development for relevant disorders.
Immunodeficiency: Complement disorders.
Allergy Asthma Proc
September 2024
From the Allergy and Immunology Service, Walter Reed National Military Medical Center, Bethesda, Maryland; and.
Article Synopsis
- * Deficiencies or abnormalities in complement proteins can lead to health issues like increased infection risk, autoimmune diseases, and thrombosis, depending on which protein is affected.
- * Diagnosis is done through functional assays to assess overall complement activity and specific factors, while management includes vaccinations, antibiotics, and monitoring for autoimmune conditions.
Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid Arthritis.
Int J Mol Sci
July 2024
Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain.
The complement (C) system is implicated in the etiopathogenesis of rheumatoid arthritis (RA). However, there is a lack of studies characterizing all three C pathways in RA patients. This study aimed to evaluate the association between an in-depth examination of the C system and RA patient characteristics, focusing on disease activity and the presence of rheumatoid factor and anti-citrullinated protein autoantibodies (ACPA).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!