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Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.
J Clin Invest
January 2025
Department of Medicine, University of California San Francisco, San Francisco, United States of America.
Hypoxia is a major cause of pulmonary hypertension (PH) worldwide, and it is likely that interstitial pulmonary macrophages contribute to this vascular pathology. We observed in hypoxia-exposed mice an increase in resident interstitial macrophages, which expanded through proliferation and expressed the monocyte recruitment ligand CCL2. We also observed an increase in CCR2+ macrophages through recruitment, which express the protein thrombospondin-1 that functionally activates TGF-beta to cause vascular disease.
View Article and Find Full Text PDFSalt and Nutritional Content of Foods Advertised During Televised Professional Football Games.
JAMA Netw Open
January 2025
University of Nevada, Reno School of Medicine, Reno.
Antidepressant Use Before, During, and After Pregnancy.
JAMA Netw Open
January 2025
University of Chicago Booth School of Business, Chicago, Illinois.
Community Racial and Ethnic Representation Among Physicians in US Internal Medicine Residency Programs.
JAMA Netw Open
January 2025
Ronald O. Perelman Department of Emergency Medicine, New York University Langone Health, New York.
Importance: Increasing underrepresented in medicine (URIM) physicians among historically underserved communities helps reduce health disparities. The concordance of URIM physicians with their communities improves access to care, particularly for American Indian and Alaska Native, Black, and Hispanic or Latinx individuals.
Objectives: To explore county-level racial and ethnic representation of US internal medicine (IM) residents, examine racial and ethnic concordance between residents and their communities, and assess whether representation varies by presence of academic institutions or underserved settings.
Cross-cultural validity of the Five-Factor Personality Inventory for ICD-11 across nine countries and validation of a French translation.
Personal Disord
January 2025
Laboratoire sur les Interactions Cognition, Action, Émotion (LICAE), UFR STAPS, Universite Paris-Nanterre.
This study aimed to assess measurement invariance for the Five-Factor Inventory for (Oltmanns & Widiger, 2020) across nine national samples from four continents ( = 6,342), and to validate a French translation in seven French-speaking national samples. All were convenience samples of adults. Exploratory factor analyses supported a four-factor structure in the French-speaking Western samples (Belgium, Canada, France, and Switzerland) while a three-factor structure was preferred in the French-speaking African samples (Burkina Faso and Togo), and no adequate structure was found in the Indian sample.
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