Light microscopy is usually considered sufficient for the diagnosis of medullary carcinoma of the thyroid (MCT). As stromal amyloid is not always present and the tumor may exhibit great variation in growth pattern, light microscopy alone, however, may lead to misinterpretations. Of 1670 thyroid carcinomas registered durging a 15-year period in Norway, 42 were originally interpreted as MCT. The slides were reviewed and the diagnosis maintained in 33 cases only. Twenty-four additional cases were found by reviewing histopathologic slides from neoplasms originally registered as other types of thyroid tumors. Of 57 cases of MCT, stromal amyloid was demonstrated in 43. Calcitonin measurements and electron microscopy, even on formalin-fixed material, were valuable aids in establishing the correct diagnosis, though none of these methods are unequivocal. Different aspects of the problems concerning the diagnosis of MCT are discussed through the detailed presentation of five patients.
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http://dx.doi.org/10.1002/1097-0142(197607)38:1<366::aid-cncr2820380153>3.0.co;2-r | DOI Listing |
Endocr Oncol
January 2025
Department of Endocrinology. Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Medullary thyroid carcinoma (MTC) is a rare cancer of the thyroid's calcitonin-producing C cells. This review covers recent advances in MTC treatment, emphasizing surgical and systemic therapies. For localized MTC, surgery remains the primary and most effective treatment, with total thyroidectomy and lymph node dissection providing the highest potential for cure.
View Article and Find Full Text PDFJ Appl Toxicol
March 2025
Research and Development, Drug Safety R&D, Pfizer, Cambridge, Massachusetts, USA.
In rats, thyroid tumors are common age-related findings with reported incidence rates up to 8.1% and 11.86% for follicular and C-cell adenomas, respectively.
View Article and Find Full Text PDFZhongguo Yi Xue Ke Xue Yuan Xue Bao
February 2025
Department of Pathology,Quanzhou, Fujian 362000,China.
Objective To analyze the cellular and histopathological characteristics of underdiagnosed thyroid nodules of Chinese thyroid imaging reporting and data system(C-TIRADS) categories 3 and 4a,thus improving the understanding of these lesions. Methods The data of ultrasound and fine needle aspiration cytology were collected from 683 nodules diagnosed based on pathological evidence in 549 patients undergoing thyroid surgery.The cellular and histopathological characteristics of C-TIRADS 3 and 4a nodules were analyzed.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
January 2025
Oral and Maxillofacial Surgery, Khandelwal Dental Clinic and Implant Center, Noida, Uttar Pradesh India.
To analyze the correlation of age, gender, subsite, and histopathological factors such as tumour grade, depth of invasion (DOI), lymphovascular invasion(LVI), perineural invasion(PNI), bone invasion and worst pattern of invasion(WPOI) with cervical lymph node metastasis(LNM), extranodal extension(ENE), lymph node ratio(LNR), number of positive nodes(+ veN) and T stage in oral squamous cell carcinoma (OSCC). We conducted a retrospective study on cases with OSCC of all stages and any designated anatomical subsite of the oral cavity, who reported to us from the year 2018-2023, and underwent curative-intent surgery with or without appropriate adjuvant treatment. Various clinic-pathological parameters were recorded and their correlation with lymph node metastasis, lymph node ratio(LNR), number of positive nodes(+ veN), extranodal extension(ENE) and T stage was analyzed.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
February 2025
Department of Pediatric Hematology and Oncology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czechia.
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