Rapid neurite retraction and transient rounding of serum-starved NG108-15 and PC12 cells by lysophosphatidic acid (LPA) is retarded and reduced by pre-incubation of the cells with the small non-peptidic molecule, SR 57746A, which exhibits neurotrophic properties. The compound also antagonizes the redistribution of filamentous actin by LPA in both cell types. We hypothesize that the SR 57746A attenuation of LPA-induced effects may account for at least some of the neuroprotective properties of this molecule.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0169-328x(97)00299-4 | DOI Listing |
Publication Analysis
Top Keywords
neurite retraction
8
inhibition lysophosphatidic
4
lysophosphatidic acid-induced
4
acid-induced neurite
4
retraction cell
4
cell rounding
4
rounding 57746a
4
57746a rapid
4
rapid neurite
4
retraction transient
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!