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Integration of non-randomized studies with randomized controlled trials in meta-analyses of clinical studies: a meta-epidemiological study on effect estimation of interventions.
BMC Med
December 2024
Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- * Researchers examined 220 systematic reviews published between December 2017 and December 2022, focusing on different clinical scenarios where NRSIs were justified for inclusion, with adverse outcomes being the most common reason.
- * Findings revealed that a significant portion of reviews did not assess compatibility before combining evidence types, leading to discrepancies in estimates; 35.5% showed qualitative disagreement and 46.5% indicated important differences between NRSIs and RCTs.
Blinding Assessments in Neonatal Ventilation Meta-Analyses: A Systematic Meta-Epidemiological Review.
Neonatology
December 2024
Division of Pediatrics and Neonatal Critical Care, "A. Beclere" Hospital, APHP-Paris Saclay University, Paris, France.
Introduction: Randomization and blinding are generally important in randomized trials. In neonatology, blinding of ventilation strategies is unfeasible if not impossible and we hypothesized that its importance has been overestimated, while the peculiarities of the neonatal patient and the specific outcomes have not been considered.
Methods: For this meta-epidemiological review, we searched PubMed and Scopus databases in November 2023.
High certainty evidence is stable and trustworthy, whereas evidence of moderate or lower certainty may be equally prone to being unstable.
J Clin Epidemiol
July 2024
Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA; Department of Clinical Research, University of Basel, University Hospital Basel, Basel, Switzerland; Pragmatic Evidence Lab, Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland; Meta-Research Innovation Center Berlin (METRIC-B), Berlin Institute of Health, Berlin, Germany.
Objectives: To assess to what extent the overall quality of evidence indicates changes to observe intervention effect estimates when new data become available.
Methods: We conducted a meta-epidemiological study. We obtained evidence from meta-analyses of randomized trials of Cochrane reviews addressing the same health-care question that was updated with inclusion of additional data between January 2016 and May 2021.
Prevalence of and factors associated with potentially redundant randomized controlled trials: a cross-sectional study.
J Clin Epidemiol
March 2024
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Article Synopsis
- The study aimed to determine how common it is for meta-analyses to include randomized controlled trials (RCTs) that may be redundant—meaning they started after a key result had already been established in previous studies.
- The research involved analyzing a sample of 4,500 references from recent systematic reviews and meta-analyses published in major medical databases, ultimately focusing on 448 eligible meta-analyses of interventions combining RCTs only.
- Out of the analyzed meta-analyses, 12.7% were found to contain potentially redundant RCTs, amounting to a total of 295 potentially redundant trials involving over 85,000 participants, suggesting a significant degree of overlap in the data used across these studies. *
Association of overweight, obesity and risk of urinary incontinence in middle-aged and older women: a meta epidemiology study.
Front Endocrinol (Lausanne)
October 2023
Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Aims: The aim of this meta-analysis is to evaluate the potential correlation between obesity and overweight, and the vulnerability to urinary incontinence (UI) in women aged middle-aged and above.
Methods: We searched PubMed, Cochrane Library, and Embase for observational studies published between the inception of the databases and April 25, 2023. A fixed-effects model was used when the P>0.
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