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Probiotics combined with prebiotics alleviated seasonal allergic rhinitis by altering the composition and metabolic function of intestinal microbiota: a prospective, randomized, double-blind, placebo-controlled clinical trial.
Front Immunol
November 2024
Department of Respiratory and Critical Care Medicine, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, China.
Background: Numerous studies have established that probiotics or prebiotics can relieve the symptoms of allergic rhinitis (AR), but their mechanism of action remain underexplored. This study aimed to observe the clinical efficacy of probiotics combined with prebiotics in seasonal AR patients and explore their underlying mechanisms.
Methods: We conducted a prospective, randomized, double-blind, placebo-controlled clinical trial.
Comparative Efficacy of Mometasone Nasal Spray Combined with Different Doses of Desloratadine, and Montelukast in Childhood Allergic Rhinitis: A Randomized Clinical Trial.
Iran J Allergy Asthma Immunol
July 2024
Division of Allergy and Clinical Immunology, Department of Pediatrics, Bahrami Children's Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Allergic rhinitis is a common issue in children, and while several medications like nasal corticosteroids and antihistamines are used to treat it, there's ongoing debate about the best dosage and combinations for maximum effectiveness.* -
- A study involving 64 children compared the effects of different drug combinations alongside mometasone furoate nasal spray, measuring symptoms like nasal congestion and sneezing.* -
- Results showed that using desloratadine twice daily or a combination of desloratadine and montelukast significantly improved symptom control compared to other treatment options.*
Objective: To assess the efficacy of combining acupuncture with pricking blood therapy to treat chronic spontaneous urticaria (CSU) and compare its outcomes with those of second-generation H1-antihistamines.
Methods: Seventy CSU patients were enrolled and randomly assigned to receive treatment with either oral loratadine tablets or a combination of acupuncture and pricking blood therapy (n=35 each). Evaluations were conducted at baseline, at the conclusion of the 4-week treatment period, and at the 4th and 8th weeks post-treatment time points.
[Effect of acupuncture combined with bloodletting therapy on mast cell degranulation in urticaria rats].
Zhongguo Zhen Jiu
November 2024
Department of Acupuncture and Moxibustion, First Affiliated Hospital of Hebei University of CM, Shijiazhuang 050011.
Article Synopsis
- The study aimed to investigate the impact of combining acupuncture and bloodletting on inflammatory responses in rats diagnosed with urticaria, focusing on serum markers and skin tissue characteristics.
- Using 42 SD rats, researchers divided them into six groups: a control, a model, a positive drug, an acupuncture, a bloodletting, and a combined treatment group, with specific interventions administered for 14 days.
- After treatment, the researchers measured various inflammatory markers, assessed the skin damage, and analyzed the activity of mast cells to evaluate the effectiveness and potential mechanisms of this therapy for urticaria.
The Effects of Nebivolol-Gefitinib-Loratadine Against Lung Cancer Cell Lines.
In Vivo
October 2024
Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Ciudad de México, México;
Article Synopsis
- * This study tested the combination of the antihistamine loratadine, beta-blocker nebivolol, and tyrosine-kinase inhibitor gefitinib on NSCLC cell lines A-549 and NCI-H1975, observing significant anti-cancer effects.
- * The combination therapy effectively inhibited cell growth and increased apoptosis in both NSCLC cell lines, suggesting that this trio of drugs could be a promising alternative for treating lung cancer.
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