The protective effect of natural dipeptide carnosine on gastric and duodenal mucosal lesions induced by acetic acid application was studied on rats. An increase in total area of the erosions on the stomach and duodenum was significantly inhibited by oral and intraperitoneal administration of carnosine. In addition, carnosine normalized the level of amino acids undergoing change during gastric mucosal injury. Histological evidence showed effective healing of the mucosal defects as a result of carnosine administration.
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