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An (un)answered cry for help: a qualitative study exploring the subjective meaning of eating disorders in the context of transgenerational trauma.
J Eat Disord
January 2025
Bodywhys - The Eating Disorders Association of Ireland, 105, Blackrock, Co. Dublin, Ireland.
Background: Current research on the transmission of trauma and eating disorders across generations is limited. However, quantitative studies suggest that the influence of parents' and grandparents' eating disorders and their prior exposure to trauma are associated with the development of eating disorders in future generations. Qualitative research exploring personal accounts of the impact of transgenerational trauma on the development of eating disorders has been largely unexplored.
View Article and Find Full Text PDFClinical evaluation of long-read sequencing-based episignature detection in developmental disorders.
Genome Med
January 2025
Laboratory of Cytogenetics and Genome Research, Centre for Human Genetics, KU Leuven, Leuven, 3000, Belgium.
Background: A subset of developmental disorders (DD) is characterized by disease-specific genome-wide methylation changes. These episignatures inform on the underlying pathogenic mechanisms and can be used to assess the pathogenicity of genomic variants as well as confirm clinical diagnoses. Currently, the detection of these episignature requires the use of indirect methylation profiling methodologies.
View Article and Find Full Text PDFImplementing Namaste Care in nursing care homes for people with advanced dementia: a systematically constructed review with framework synthesis.
BMC Geriatr
January 2025
International Observatory on End of Life Care, Lancaster University, Lancaster, UK.
Background: Namaste Care is an intervention designed to improve the quality of life for people with advanced dementia by providing individualised stimulation and personalised activities in a group setting. Current evidence indicates there may be benefits from this intervention, but there is a need to explore the practical realities of its implementation, including potential barriers, enablers, and how it is delivered within the context of nursing care homes.
Objective: To systematically assess the factors involved in implementing Namaste Care for people with advanced dementia in nursing care homes.
Conditional Deletion of Gremlin-1 in Cathepsin K-expressing Mature Osteoclasts Altered the Skeletal Response to Calcium Depletion in Sex-Dependent Manner.
Calcif Tissue Int
January 2025
Musculoskeletal Disease Center (151), Jerry L. Pettis Memorial VA Medical Center, VA Loma Linda Healthcare System, 11201 Benton Street, Loma Linda, CA, 92357, USA.
This study assessed the novel concept that osteoclast-derived Grem1 has regulatory functions in the skeletal response to calcium stress using an osteoclastic Grem1 conditional knockout (cKO) mouse model. The calcium stress was initiated by feeding cKO mutants and wildtype (WT) littermates a calcium-deficient diet for 2 weeks. Deletion of Grem1 in mature osteoclasts did not affect developmental bone growth nor basal bone turnover.
View Article and Find Full Text PDFElectrosynthesis of Organonitrogen Compounds via Hydroxylamine-Mediated Cascade Reactions.
Angew Chem Int Ed Engl
January 2025
Hunan University, Chemical Engineering, Lushan South Road, 410082, Changsha, CHINA.
Hydroxylamine (NH2OH) is a key intermediate in the formation of numerous high value-added organonitrogen compounds. The traditional synthesis of NH2OH requires the use of precious metals under high temperature conditions, which leads to high cost, high energy consumption, and environmental pollution. The NH2OH-mediated cascade reaction integrates the electrochemical synthesis of NH2OH and the chemical synthesis of organonitrogen compounds, offering a facile, green, and efficient alternative.
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