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Stenotrophomonas maltophilia sepsis in preterm neonates.
Med J Armed Forces India
December 2024
Professor (Neonatology), Bharati Vidyapeeth Medical College, Deemed to be University, Pune, India.
, an environmentally ubiquitous microbe, is a challenging opportunistic pathogen in the hospital setting. Neonates are particularly vulnerable to infection with but information on presentation, therapeutic response and outcome of such infection in this population is limited. To expand this knowledge, we report here a series of five cases.
View Article and Find Full Text PDFEffects of Saprolegnia parasitica on pathological damage and metabolism of Epithelioma papulosum cyprini cell.
Dev Comp Immunol
December 2024
National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, China; National Pathogen Collection Center for Aquatic Animals, Shanghai Ocean University, Shanghai, China; Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Shanghai Ocean University, Shanghai, China. Electronic address:
Saprolegniasis is a common fungal disease in aquaculture. It will form white flocculent hyphae on the skin of fish, and the hyphae may grow inward and penetrate into muscle tissue, which will reduce the immunity of the body and eventually lead to death. However, there are still some gaps in the mechanism of the fish body surface against the invasion of Saprolegnia.
View Article and Find Full Text PDFStrategy and Design of In Situ Activated Protein Hydrolysis Targeted Chimeras.
ACS Nano
December 2024
Faculty of Materials Science, Shenzhen MSU-BIT University, Shenzhen 518100, P. R. China.
Protein hydrolysis targeted chimeras (PROTACs) represent a different therapeutic approach, particularly relevant for overcoming challenges associated with traditional small molecule inhibitors. These challenges include targeting difficult proteins that are often deemed "undruggable" and addressing issues of acquired resistance. PROTACs employ the body's own E3 ubiquitin ligases to induce the degradation of specific proteins of interest (POIs) through the ubiquitin-proteasome pathway.
View Article and Find Full Text PDFHuman Fascioliasis in Portugal: A Case Report.
Cureus
November 2024
Internal Medicine, Hospital Conde de Bertiandos, Unidade Local de Saúde do Alto Minho, Ponte de Lima, PRT.
Fascioliasis is a zoonotic disease that may affect humans as incidental hosts after the ingestion of contaminated water or aquatic plants. Despite the non-specificity of its signs and symptoms, a triad of abdominal pain, fever, and peripheral eosinophilia should increase suspicion. The diagnosis of fascioliasis can be particularly difficult in non-endemic countries.
View Article and Find Full Text PDFChanges in the cortical GABAergic inhibitory system with ageing and ageing-related neurodegenerative diseases.
J Physiol
December 2024
Department of Neuroscience and Movement Science, University of Fribourg, Fribourg, Switzerland.
The human cortical inhibitory system is known to play a vital role for normal brain development, function, and plasticity. GABA is the most prominent inhibitory neurotransmitter in the CNS and is a key regulator not only for motor control and motor learning, but also for cognitive processes. With ageing and many neurodegenerative pathologies, a decline in GABAergic function in several cortical regions together with a reduced ability to task-specifically modulate and increase inhibition in the primary motor cortex has been observed.
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