A new case of C1 inhibitor deficiency is described, pointing out the relationship between laboratory and radiological findings (increase haemoglobin and hematocrit index, and BUN) and presence of free intraperitoneal fluid (ultrasonography and radiology). In patients with this rate condition undergoing laparotomy because acute appendicitis or other surgical condition suspected, the evidence of massive intraperitoneal effusion should indicate the possibility of C1 inhibitor deficiency.

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