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Brain state-dependent neocortico-hippocampal network dynamics are modulated by postnatal stimuli.
J Neurosci
January 2025
Department of Integrative Anatomy, Nagoya City University Graduate School of Medicinal Sciences.
Neurons in the cerebral cortex and hippocampus discharge synchronously in brain state-dependent manner to transfer information. Published studies have highlighted the temporal coordination of neuronal activities between the hippocampus and a neocortical area, however, how the spatial extent of neocortical activity relates to hippocampal activity remains partially unknown. We imaged mesoscopic neocortical activity while recording hippocampal local field potentials in anesthetized and unanesthetized GCaMP-expressing transgenic mice.
View Article and Find Full Text PDFUncovering the naturally occurring covalent inhibitors of SARS-CoV-2 M from the Chinese medicine sappanwood and deciphering their synergistic anti-M effects.
J Ethnopharmacol
January 2025
Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, 310014. Electronic address:
Ethnopharmacological Relevance: The Chinese medicine sappanwood is primarily sourced from the dried heartwood of the medicinal plant Caesalpinia sappan Linn., which has been found with a variety of valuable properties including anti-inflammatory, anti-oxidant, and anti-viral effects. Preliminary investigations have demonstrated that sappanwood showed strong anti-SARS-CoV-2 M effects, but the key constituents responsible for SARS-CoV-2 M inhibition and their anti-M mechanisms have not been uncovered.
View Article and Find Full Text PDFIsolation and identification of pigeon adenovirus 1 and analysis of its pathogenicity in pigeons and chickens.
Microb Pathog
January 2025
College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong Province, 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai'an, Shandong, 271018, China; Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai'an, Shandong, 271018, China. Electronic address:
Pigeon adenovirus type 1 predominantly infects pigeons under 12 months of age (mainly 3-5 months old), causing major clinical symptoms such as vomiting, dehydration, and discharge of thin yellow feces. In February 2023, an outbreak of a pathogen with symptoms similar to pigeon adenovirus infections occurred on a pigeon farm in Shandong Province, which was eventually identified as pigeon adenovirus type 1. In this study, a strain of PiAdV-1 was isolated from naturally infected pigeons and named pigeon-adenovirus-1-isolate-CH-SD-2023, and the hexon gene sequence as amplified and analyzed using polymerase chain reaction (PCR).
View Article and Find Full Text PDFA giant fibro epithelial polyp of the vulva: A case report.
Int J Surg Case Rep
January 2025
Dilla University, College of Medicine and Health Sciences, Department of Obstetrics and Gynecology, Dilla, Ethiopia.
Introduction And Importance: Fibroepithelial polyps are benign growths that can occur in various anatomical locations, including the vulva. They typically present as asymptomatic skin tags that progressively increase in size.
Case Presentation: We report the case of a 30-year-old woman, para 3, who presented with a giant fibroepithelial polyp originating from the right labium majora.
p-Phenylenediamines and their derived quinones: A review of their environmental fate, human exposure, and biological toxicity.
J Hazard Mater
January 2025
College of Environment and Resources, College of Carbon Neutral, Zhejiang A & F University, Hangzhou 311300, China.
p-Phenylenediamines (PPDs) are widely used as antioxidants in numerous rubber products to prevent or delay oxidation and corrosion. However, their derived quinones (PPD-Qs), generated through reactions with ozone, are ubiquitous in the environment and raise significant health and toxicity concerns. This review summarizes the current state of knowledge on environmental distribution and fate, human exposure, and biological toxicity of PPDs and PPD-Qs, and makes recommendations for future research directions.
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