Analysis is presented discussing why there is an absence of fundamental endocrinology in Russian science. Features of the session of the Academy of Sciences and the Lenin All-Union Academy of Agricultural Sciences (1948) and of the session of the Academy of Sciences and Academy of Medical Sciences (1950) and their influence on the development of science are considered. The less infamous Pavlov's session (1950) has had a more destructive influence on the development of endocrinology than Michurin's session has on the development of genetics. The prospects for development in Russia of fundamental endocrinology as of a branch of matrix biology are estimated pessimistically. At present, endocrinology has become a general biological science about hormones as the main regulators of vital processes. Specific hormones are generated by all organs, tissues, and cells of living organisms, functioning as means for communication between organs and tissues, and together with the nervous system unite them into a single whole.
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Nutr Metab (Lond)
January 2025
Shenzhen Center for Chronic Disease Control, No. 2021 Buxin Road, Luohu District, Shenzhen, 518020, China.
Background: Serum vitamin D deficiency is intricately linked to metabolic disorders, however, evidence on its association with continuous metabolic risk in children and adolescents remains insufficient. This study aims to elucidate the relationship between serum vitamin D levels and continuous metabolic risk.
Methods: The cross-sectional analysis involved 4490 participants aged 6 ~ 18, and the longitudinal investigation included 1398 individuals aged 6 ~ 12 years.
Endocrinology
January 2025
Grupo de Neurofisiología- Instituto Multidisciplinario de Biología Celular (IMBICE) (Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de La Plata, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires), La Plata, Argentina.
Liver-expressed antimicrobial peptide 2 (LEAP2) has recently emerged as a novel hormone that reduces food intake and glycemia by acting through the growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor. This discovery has led to a fundamental reconceptualization of GHSR's functional dynamics, now understood to be under a dual and opposing regulation. LEAP2 exhibits several distinctive features.
View Article and Find Full Text PDFJACC Adv
December 2024
Alliance for Medical Research in Africa, Dakar, Senegal.
This proposed scientific statement is focused on providing new insights regarding challenges and opportunities for cardiovascular health (CVH) promotion in Africa. The statement includes an overview of the current state of CVH in Africa, with a particular interest in the cardiometabolic risk factors and their evaluation through metrics. The statement also explains the main principles of primordial prevention, its relevance in reducing noncommunicable disease and the different strategies that have been effective worldwide.
View Article and Find Full Text PDFiScience
January 2025
Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai, Kita-ku, Osaka 530-8480, Japan.
Activation of thyroid-stimulating hormone receptor (TSHR) fundamentally leads to hyperthyroidism. To elucidate TSHR signaling, we conducted transcriptome analyses for hyperthyroid mice that we generated by overexpressing TSH. TSH overexpression drastically changed their thyroid transcriptome.
View Article and Find Full Text PDFClin Chim Acta
January 2025
Fundación Instituto de Investigación Sanitaria Islas Baleares (IdISBa), Hospital Universitario Son Espases, Carretera de Valldemossa, 79, 07010, Palma, Spain.
24-h urinary free cortisol (UFC) measurements are fundamental in the diagnosis and follow-up of Cushinǵs syndrome (CS) and immunoassays (IA) are the most widely used tests for its quantification in clinical laboratory practice. However, their suitability has been questioned mainly due to their limitations concerning analytical specificity. The aim of this research project was to evaluate a novel algorithm for CS diagnosis and follow-up in the clinical laboratory, based on the combination of IA tests with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for UFC quantification.
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