The recent outbreak of vaginal adenocarcinoma and the associated genital tract anomalies in women with histories of prenatal exposure to diethylstilbestrol (DES) has generated interest in vaginal embryogenesis and the influence of hormones on the developing genital tract. In this report the embryology of the vagina and the role of sex hormones in normal and abnormal sex duct development are presented and discussed in relation to the DES-induced anomalies. Although the teratogenic activity of DES in humans has been confirmed, the available evidence suggests that the clear cell carcinomas are initiated by endogenous estrogens and not the prenatally administered DES.
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Article Synopsis
- Hymeneal imperforation is a rare genital malformation identified during emergencies, often leading to symptoms like pelvic pain and primary amenorrhoea, confirmed through clinical evaluation and imaging like ultrasound.
- A 13-year-old girl experienced abdominal pain and distension due to hematocolpos caused by an imperforate hymen, requiring surgical intervention to release a significant amount of collected blood.
- If untreated, an imperforate hymen can lead to serious complications, making early diagnosis and timely surgical treatment critical, especially since symptoms commonly arise during menarche.
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