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Retraction Note: Establishment of an Acanthamoeba keratitis mouse model confirmed by amoebic DNA amplification.
Sci Rep
January 2025
Department of Microbiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.
Concomitant Potentially Contagious Factors Detected in Poland and Regarding Strains, Etiological Agents of Keratitis in Humans.
Microorganisms
November 2024
Laser Eye Microsurgery Centre Clinic of Prof. Jerzy Szaflik, 00-215 Warsaw, Poland.
Background: Diseases in humans caused by amphizoic amoebae that can result in visual impairment and even blindness, have recently been identified more frequently worldwide. Etiologically complex incidents of keratitis, including those connected with strains detected in Poland, were evaluated in this study.
Methods: Corneal samples from cases resistant to antimicrobial therapy assessed for epidemiological, microbiological and parasitological aspects were investigated by phase-contrast microscope, slit lamp and by confocal microscopy.
Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways.
Int J Parasitol Drugs Drug Resist
January 2025
Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China. Electronic address:
Acanthamoeba castellanii is a widespread unicellular eukaryote found in diverse environments, including tap water, soil, and swimming pools. It is responsible for severe infections, such as Acanthamoeba keratitis and granulomatous amebic encephalitis, particularly in individuals with immunocompromisation. The ability of protozoans to form dormant and persistent cysts complicates treatment, as current therapies are ineffective against cyst stages and suffer from poor specificity and side effects.
View Article and Find Full Text PDFExpression Analysis of Cyst Specific Protein (CSP21) and Cellulose Synthase II (CSII) Genes in Acanthamoeba castellanii Trophozoites Exposed to Silver Nanoparticles Conjugated with Elaeagnus umbellata.
Acta Parasitol
January 2025
Department of Molecular Biology and Genetics, Ordu University, Ordu, Turkey.
Article Synopsis
- Acanthamoeba species are protozoa that can cause serious eye and CNS infections, and current treatments are often ineffective, especially in specific areas like the eye.
- The study evaluates the effectiveness of ethanolic fruit extract of E. umbellata, silver nanoparticles derived from it, and lauric acid in killing Acanthamoeba trophozoites and protecting DNA from damage.
- Results show that these treatments can significantly kill trophozoites and prevent DNA damage, suggesting potential new options for treating Acanthamoeba infections.
Assessment of dynamics of pathogenic environmental T4 and T9 genotypes isolated from three recreational lakes in Klang Valley, Malaysia over the HaCaT cell monolayer.
J Water Health
December 2024
Centre for Medical Laboratory Technology Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, Selangor, Malaysia; Microbiome Health and Environment (MiHeaRT), Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia E-mail:
Free-living amoebae of the genus are causative agents of keratitis and amoebic encephalitis. They are widely found in various ecological environments. Therefore, the present study brings results that can help to better understand the genotypes of the environmental isolates and their pathogenicity.
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