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Successful desensitization to atezolizumab-induced near-fatal anaphylaxis in patients with hepatocellular carcinoma: A case report and literature review.
Asia Pac Allergy
August 2024
Department of Internal Medicine, Kosin University College of Medicine, Busan, Republic of Korea.
Atezolizumab, a humanized antiprogrammed death ligand 1 monoclonal immunoglobulin G1 antibody, is a targeted therapeutic drug known as an immune checkpoint inhibitor. It is currently used to treat various types of cancer, including unresectable hepatocellular carcinoma (HCC), nonsmall cell lung cancer, urothelial cancer, and breast cancer, and is becoming a therapeutic option in the forefront of oncology treatment. However, it may sometimes lead to undesirable adverse reactions owing to the activation of immune responses in various organs.
View Article and Find Full Text PDFDiagnosis and management of anaphylaxis.
J Food Allergy
September 2020
From the Section of Immunology, Allergy and Retrovirology, Texas Children's Hospital, Houston, Texas, and.
Article Synopsis
- * Diagnosis is based on clinical evaluation, and prevention focuses on avoiding known allergens and managing other health conditions; immediate assessment and treatment are crucial.
- * The first-line treatment is the administration of epinephrine, with specific dosage and positioning recommendations post-treatment; educating patients and families on managing anaphylaxis is essential for better outcomes.
Ceftriaxone near-fatal anaphylaxis.
Postgrad Med J
October 2024
Department of Medicine, Laniado University Hospital, Sanz Medical Centre, Netanya, Israel.
Management of Food Allergies and Food-Related Anaphylaxis.
JAMA
February 2024
Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill.
Importance: An estimated 7.6% of children and 10.8% of adults have IgE-mediated food-protein allergies in the US.
View Article and Find Full Text PDFIs Wheat Glutenin Extract Intrinsically Allergenic? Evaluation Using a Novel Adjuvant-Free Mouse Model of Systemic Anaphylaxis.
Int J Mol Sci
December 2023
Food Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USA.
Wheat is a prominent allergenic food that can trigger life-threatening anaphylaxis. Presently, it remains unclear whether wheat glutenin (WG) extract possesses inherent sensitization potential independently, without the use of adjuvants, and whether it can sensitize mice to the extent of inducing life-threatening systemic anaphylaxis. In this study, we tested the hypothesis that repeated skin exposures to WG extract without adjuvant will sensitize mice with the resultant anaphylactic reaction upon systemic WG challenge.
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