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Multivariate contaminated normal linear mixed models applied to Alzheimer's disease study with censored and missing data.
Stat Methods Med Res
January 2025
Department of Statistics and Institute of Data Science, National Cheng Kung University, Tainan, Taiwan.
The article proposes a robust approach to jointly modeling multiple repeated clinical measures with intricate features. More specifically, we aim to expand the scope of the multivariate linear mixed model by using the multivariate contaminated normal distribution. The proposed model, called the multivariate contaminated normal linear mixed model with censored and missing responses (MCNLMM-CM), is designed to handle minor outliers effectively, while simultaneously accommodating censored measurements and intermittent missing responses.
View Article and Find Full Text PDFUncovering mercury accumulation and the potential for bacterial bioremediation in response to contamination in the Singalila National Park.
Sci Rep
January 2025
Molecular Biology and Tissue Culture Laboratory, Department of Tea Science, University of North Bengal, Siliguri, West Bengal, India.
Several recent investigations into montane regions have reported on excess mercury accumulation in high-altitude forest ecosystems. This study explored the Singalila National Park, located on the Singalila ridge of the Eastern Himalayas, revealing substantial mercury contamination. Particular focus was on Sandakphu (3636 m), the highest peak in West Bengal, India.
View Article and Find Full Text PDFOptimizing nano-sized oxygen bubble application for prolonged aerobic degradation of BTEX in contaminated groundwater.
J Environ Manage
January 2025
Department of Environmental Engineering, Korea National University of Transportation, Chungju, 27469, Republic of Korea. Electronic address:
This study investigates the use of nano-sized oxygen bubbles (NOBs) to enhance BTEX (benzene, toluene, ethylbenzene, xylene) biodegradation in groundwater. Optimized NOBs, averaging 155 nm and at a concentration of 6.59 × 10⁸ bubbles/mL, were found to provide sustained oxygen release with a half-life of approximately 50 days.
View Article and Find Full Text PDFEnhancing farmer awareness: Vertical transmission of Neospora caninum in aborting cattle and the value of diagnostics tools.
Vet Parasitol
January 2025
Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, Bern 3012, Switzerland. Electronic address:
The protozoan parasite Neospora caninum is an important cause of abortion in cattle. Infection occurs horizontally by ingestion of oocysts shed by canids or vertically, from an infected dam to the foetus, and may result in abortion, stillbirth, or the birth of subclinically infected offspring. We estimated the occurrence of N.
View Article and Find Full Text PDFExploring potential targets and mechanisms of renal tissue damage caused by N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ) through network toxicology and animal experiments: A case of chronic kidney disease.
Sci Total Environ
January 2025
Department of Pediatric surgrey, Guizhou Provincial People's Hospital, Guiyang 550000, China. Electronic address:
6-PPDQ is a new type of environmental contaminant contained in tire rubber. No studies have been reported on the potential targets and mechanisms of action of 6-PPDQ on renal tissue damage. In the present study, we used CKD as an example to explore the potential targets and biological mechanisms of renal injury caused by 6-PPDQ using Network toxicology and animal experiments.
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