Thymic carcinoma metastatic to the orbit.

Am J Ophthalmol

Oculoplastics and Orbital Service, McGill University, Montreal, Quebec, Canada.

Published: September 1997

Purpose: To report a case of small cell carcinoma of the thymus metastatic to the orbit.

Methods: At age 37 years, a man who had been previously diagnosed and treated for small cell carcinoma of the thymus was initially examined for vertical diplopia and left proptosis. Computed tomographic scan disclosed a soft tissue mass in the superior aspect of the left orbit. A fine-needle aspiration biopsy of the mass was performed and submitted for cytopathologic examination.

Result: The cytopathology and immunopathology disclosed malignant cells consistent with metastatic small cell thymic carcinoma.

Conclusion: This is the first reported case of a primary thymus gland tumor metastatic to the orbit.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0002-9394(14)70836-0DOI Listing

Publication Analysis

Top Keywords

small cell
12
metastatic orbit
8
cell carcinoma
8
carcinoma thymus
8
thymic carcinoma
4
metastatic
4
carcinoma metastatic
4
orbit purpose
4
purpose report
4
report case
4

Similar Publications

NRG1 Fusions: The New Kid on the Block.

Curr Oncol Rep

January 2025

Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, 20007, USA.

Purpose Of Review: Neuregulin 1 (NRG1) fusions are rare but actionable oncogenic drivers that occur in a variety of tumor types, including non-small cell lung cancer (NSCLC). These fusions lead to pathophysiologic activation of HER signaling pathways, promoting tumor growth, invasion, and metastasis. Current evidence suggests that NRG1 fusion-positive NSCLC does not respond well to conventional treatments such as immunotherapy and chemotherapy.

View Article and Find Full Text PDF

Exopolysaccharides (EPS) produced by lactic acid bacteria with immunomodulatory potential are promising natural food additives. This study employs small-scale, 250 mL bioreactors combined with a central composite design to optimise two important bioprocess parameters, namely temperature and airflow, to achieve high yields of biomass and EPS from Lacticaseibacillus rhamnosus LRH30 (L. rhamnosus LRH30).

View Article and Find Full Text PDF

Spinal cord injury (SCI) is a severe central nervous system injury without effective therapies. PANoptosis is involved in the development of many diseases, including brain and spinal cord injuries. However, the biological functions and molecular mechanisms of PANoptosis-related genes in spinal cord injury remain unclear.

View Article and Find Full Text PDF

Non-small cell lung cancer (NSCLC) is a widespread highly malignant type of lung cancer. Conventional chemotherapeutic drugs may be accompanied by both drug resistance and serious side effects in patients. Therefore, safer and more effective medications are urgently needed for the treatment of NSCLC.

View Article and Find Full Text PDF

Deoxyribonucleic acid (DNA) serves as a repository of genetic information in cells and is a critical molecular target for various antibiotics and anticancer drugs. A profound understanding of small molecule interaction with DNA is crucial for the rational design of DNA-targeted therapies. While the molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) and molecular mechanics/generalized Born surface area (MM/GBSA) approaches have been well established for predicting protein-ligand binding, their application to DNA-ligand interactions has been less explored.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!