AI Article Synopsis
- Cloninger's 1986 and 1987 theories link novelty seeking behavior to the dopaminergic systems, particularly involving the DRD4 gene.
- Two studies previously showed a connection between novelty seeking and the DRD4 gene, but recent findings do not support this.
- In the authors' research with two New Zealand samples, they found no significant association between novelty seeking and the DRD4 gene polymorphism.
Article Abstract
Objective: In 1986 and 1987, Cloninger postulated the existence of the heritable behavioral trait of novelty seeking and its putative underpinnings in the dopaminergic systems of the ventral midbrain. Two widely reported studies found significant associations between novelty seeking and the type 4 dopamine receptor gene (DRD4), although a more recent study did not. The authors' objective was to investigate this association in two New Zealand samples.
Method: The authors studied two nonoverlapping samples: subjects in a depression treatment trial (N = 86) and subjects from 14 pedigrees dense with alcoholism (N = 181). DRD4 genotyping was based on a standard protocol.
Results: Novelty seeking and DRD4 were not statistically associated.
Conclusions: In these samples, there was no suggestion that the DRD4 polymorphism contributed to individual differences in the behavioral trait of novelty seeking.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1176/ajp.155.1.98 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the impact of deleterious missense nonsynonymous single nucleotide polymorphisms in the DRD4 gene using computational approaches.
Sci Rep
January 2025
Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh.
Dopamine receptor D4 (DRD4) plays a vital role in regulating various physiological functions, including attention, impulse control, and sleep, as well as being associated with various neurological diseases, including attention deficit hyperactivity disorder, novelty seeking, and so on. However, a comprehensive analysis of harmful nonsynonymous single nucleotide polymorphisms (nsSNPs) of the DRD4 gene and their effects remains unexplored. The aim of this study is to uncover novel damaging missense nsSNPs and their structural and functional effects on the DRD4 receptor.
View Article and Find Full Text PDFVentral hippocampus to nucleus accumbens shell circuit regulates approach decisions during motivational conflict.
PLoS Biol
January 2025
Department of Cell and Systems Biology, University of Toronto, Toronto, Canada.
Successful resolution of approach-avoidance conflict (AAC) is fundamentally important for survival, and its dysregulation is a hallmark of many neuropsychiatric disorders, and yet the underlying neural circuit mechanisms are not well elucidated. Converging human and animal research has implicated the anterior/ventral hippocampus (vHPC) as a key node in arbitrating AAC in a region-specific manner. In this study, we sought to target the vHPC CA1 projection pathway to the nucleus accumbens (NAc) to delineate its contribution to AAC decision-making, particularly in the arbitration of learned reward and punishment signals, as well as innate signals.
View Article and Find Full Text PDFTowards a characterization of human spatial exploration behavior.
Behav Res Methods
January 2025
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
Spatial exploration is a complex behavior that can be used to gain information about developmental processes, personality traits, or mental disorders. Typically, this is done by analyzing movement throughout an unknown environment. However, in human research, until now there has been no overview on how to analyze movement trajectories with regard to exploration.
View Article and Find Full Text PDFCentral amygdala NPBWR1 neurons facilitate social novelty seeking and new social interactions.
Sci Adv
January 2025
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
The formation of new social interactions is vital for social animals, but the underlying neural mechanisms remain poorly understood. We identified CeA neurons, a population in central amygdala expressing neuropeptide B/W receptor-1 (NPBWR1), that play a critical role in these interactions. CeA neurons were activated during encounters with unfamiliar, but not with familiar, mice.
View Article and Find Full Text PDFIntegrating intuitionistic fuzzy and MCDM methods for sustainable energy management in smart factories.
PLoS One
January 2025
Department of Business Administration, College of Business Administration, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Improving energy efficiency is crucial for smart factories that want to meet sustainability goals and operational excellence. This study introduces a novel decision-making framework to optimize energy efficiency in smart manufacturing environments, integrating Intuitionistic Fuzzy Sets (IFS) with Multi-Criteria Decision-Making (MCDM) techniques. The proposed approach addresses key challenges, including reducing carbon footprints, managing operating costs, and adhering to stringent environmental standards.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!