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Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Washington State University, Pullman, WA, USA.
Background: To promote caregiver health and reduce burden, the Savvy Caregiver Program (SCP), an evidence-based caregiving intervention, was adapted with a Native Hawaiian (NH) community in Hawai'i. The adaptation process occurred prior to pilot testing in two phases: 1) the preliminary adaptation by a community action board (CAB) and mentorship team and 2) pre-pilot testing and expert validation with NH adults. The preliminary adaptation, titled 'Auamo Kuleana O Nā Ma'i Poina ('Auamo Kuleana), aimed to include Hawaiian values, language, proverbs, and culturally relevant examples while maintaining the core components of the program.
View Article and Find Full Text PDFSingle-cell analysis of lung epithelial cells reveals age and cell population-specific responses to SARS-CoV-2 infection in ciliated cells.
Clin Exp Immunol
January 2025
Translational Biomedical Sciences Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Introduction: The ability of SARS-CoV-2 to evade antiviral immune signaling in the airway contributes to the severity of COVID-19 disease. Additionally, COVID-19 is influenced by age and has more severe presentations in older individuals. This raises questions about innate immune signaling as a function of lung development and age.
View Article and Find Full Text PDFIn vivo enhancement of tumour-specific T cells via peptide-MHC-pseudotyped retroviral gene delivery.
Nat Rev Immunol
January 2025
Preprint Club, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Three-dimensional architecture and linearized mapping of vibrissa follicle afferents.
Nat Commun
January 2025
Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Understanding vibrissal transduction has advanced by serial sectioning and identified afferent recordings, but afferent mapping onto the complex, encapsulated follicle remains unclear. Here, we reveal male rat C2 vibrissa follicle innervation through synchrotron X-ray phase contrast tomograms. Morphological analysis identified 5% superficial, ~32 % unmyelinated and 63% myelinated deep vibrissal nerve axons.
View Article and Find Full Text PDFPremature birth changes wiring constraints in neonatal structural brain networks.
Nat Commun
January 2025
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Structural brain organization in infancy is associated with later cognitive, behavioral, and educational outcomes. Due to practical limitations, such as technological advancements and data availability of fetal MRI, there is still much we do not know about the early emergence of topological organization. We combine the developing Human Connectome Project's large infant dataset with generative network modeling to simulate the emergence of network organization over early development.
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