Statistically significant correlations have been demonstrated between carcinogenic activity, toxicity and number of carbons per molecule for an extensive set of nitrosamines. Such correlations, involving only bulk molecular properties indicate that the chemical nature of the alkyl substituents need not be the sole determinants of carcinogenic activity. These structure-activity relationships can be used to estimate carcinogenic activity with some degree of confidence.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024977 | PMC |
| http://dx.doi.org/10.1038/bjc.1976.44 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Quantitative source apportionment and health risk assessment for polycyclic aromatic hydrocarbon and their derivatives in indoor dust from housing and public buildings of a mega-city in China.
J Hazard Mater
December 2024
School of Environment, Nanjing Normal University, Jiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response Technology, Nanjing 210023, China. Electronic address:
Indoor dust can adsorb various pollutants and long-term deposition can significantly impact air quality and human health. This study investigated the occurrence, source apportionment, and health risks associated with polycyclic aromatic hydrocarbons (PAHs) and their derivatives (d-PAHs) in indoor dust, by focusing on residential and public buildings in Nanjing, China. The concentration of 16 PAHs and 27 d-PAHs ranged from 511 to 5472 ng/g and from 422 to 2904 ng/g, with the most abundant compounds being fluoranthene and 1,2-benz[a]anthraquinone, respectively.
View Article and Find Full Text PDFTopological analysis and predictive modeling of amino acid structures with implications for bioinformatics and structural biology.
Sci Rep
January 2025
Department of Mathematics, College of Natural and Computational Sciences, Wollega University, Nekemte, Ethiopia.
Amino acids, as the fundamental constituents of proteins and enzymes, play a vital role in various biological processes. Amino acids such as histidine, cysteine, and methionine are known to coordinate with metal ions in proteins and enzymes, playing critical roles in their structure and function. In metalloproteins, metal ions are often coordinated by specific amino acid residues, contributing to the protein's stability and catalytic activity.
View Article and Find Full Text PDFEarly neutrophil activation and NETs release in the pristane-induced lupus mice model.
PLoS One
January 2025
Laboratório de Imunologia Celular (LIM-17), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Article Synopsis
- The study investigates the role of NETosis in the initiation of lupus using a mouse model.
- Mice injected with pristane showed significantly more activated neutrophils and low-density granulocytes, as well as increased release of neutrophil extracellular traps compared to the control group.
- These findings suggest that early activation of neutrophils and NETosis may contribute to the development of lupus in this model.
Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway.
Elife
January 2025
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Cigarette smoking is a well-known risk factor inducing the development and progression of various diseases. Nicotine (NIC) is the major constituent of cigarette smoke. However, knowledge of the mechanism underlying the NIC-regulated stem cell functions is limited.
View Article and Find Full Text PDFIntegrated environmental and health assessment from hydrogeochemistry and radiogeology parameters of hydrothermal spring attractions in Southern Thailand.
Environ Geochem Health
January 2025
Nuclear Technology Research and Development Center, Thailand Institute of Nuclear Technology, Nakhon Nayok, 26120, Thailand.
The present study aimed to investigate the hydrogeochemical patterns and contamination of the radiogeology, especially radon activity, related to geothermal aquifer properties and to perform a risk assessment of annual effective doses covering all hydrothermal spring attractions in Southern Thailand. Radon is an established lung carcinogen; especially longer term exposure to radioactive radon through inhalation could be a cause of lung cancer risk. Altogether 22 hydrothermal spring samples were collected from the six hydrothermal provinces in Southern Thailand in early November of 2023.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!