Clearing of the middle ear fluid in patients with acute otitis media due to Streptococcus pneumoniae or Haemophilus influenzae was significantly associated with the presence and concentration of specific antibody in the middle ear fluid at the time of diagnosis.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC274454PMC
http://dx.doi.org/10.1128/jcm.4.3.306-308.1976DOI Listing

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