AI Article Synopsis
- Healthy individuals produce immunoglobulins that can bind to Plasmodium falciparum-infected red blood cells.
- A study in Gabon examined 207 children with malaria, both anemic and nonanemic, to explore this binding phenomenon.
- The findings showed that 83% of the infected isolates had surface Ig binding, but no significant difference was found between anemic and nonanemic children, although extensive binding was predominantly seen in moderately anemic cases.
Article Abstract
Immunoglobulins (Ig) from healthy, nonimmune individuals bind to the surfaces of Plasmodium falciparum-infected erythrocytes (RBC). In order to investigate the presence of this parasite phenotype in wild isolates and its potential association with malarial anemia, we conducted a study of 207 anemic or nonanemic children with malaria in Gabon. Surface Ig binding to infected RBC was detected for 83% of the isolates. No difference in Ig binding between the groups was observed, but all isolates which exhibited extensive Ig binding were found in a group of moderately anemic children.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC107901 | PMC |
| http://dx.doi.org/10.1128/IAI.66.1.361-363.1998 | DOI Listing |
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