Purpose: To test whether changes in the percentage of oxygenated hemoglobin (%HbO2) and blood flow in the superior mesenteric vein (SMV), as measured with magnetic resonance (MR) imaging in vivo, can be used to diagnose and monitor mesenteric ischemia due to hemorrhagic shock in a canine model.
Materials And Methods: Eight mongrel dogs (weight range, 20-30 kg) underwent fasting for 24 hours before the experiments. MR imaging measurements of SMV %HbO2 and volume flow rate were obtained at the resting state and after 5%, 10%, and 15% of the blood volume of the dogs had been removed sequentially, which led to a total blood volume depletion of 30%. In four dogs, resuscitation was performed with normal saline solution in a volume equal to the total volume of blood removed.
Results: SMV %HbO2 and SMV flow measurements at the different stages of blood removal were all significantly different (P < .05) from baseline measurements and from each other. After volume replacement with normal saline solution, SMV %HbO2 and flow were not significantly different (P > .05) from the baseline values.
Conclusion: SMV %HbO2 and volume flow rate, as measured with MR imaging in vivo, can be used to diagnose and monitor mesenteric ischemia due to hemorrhagic shock in a canine model.
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Mesenteric ischemia due to hemorrhagic shock: MR imaging diagnosis and monitoring in a canine model.
Radiology
January 1998
Department of Radiology, Stanford University School of Medicine, CA 94305, USA.
Purpose: To test whether changes in the percentage of oxygenated hemoglobin (%HbO2) and blood flow in the superior mesenteric vein (SMV), as measured with magnetic resonance (MR) imaging in vivo, can be used to diagnose and monitor mesenteric ischemia due to hemorrhagic shock in a canine model.
Materials And Methods: Eight mongrel dogs (weight range, 20-30 kg) underwent fasting for 24 hours before the experiments. MR imaging measurements of SMV %HbO2 and volume flow rate were obtained at the resting state and after 5%, 10%, and 15% of the blood volume of the dogs had been removed sequentially, which led to a total blood volume depletion of 30%.
Chronic mesenteric ischemia: use of in vivo MR imaging measurements of blood oxygen saturation in the superior mesenteric vein for diagnosis.
Radiology
July 1997
Department of Radiology, Stanford University Medical Center, CA 94305, USA.
Purpose: To determine if dogs and humans with chronic mesenteric ischemia demonstrate a decrease in the percentage of oxygenated hemoglobin (%HbO2) in the superior mesenteric vein (SMV) after a meal.
Materials And Methods: In 10 dogs, ameroid rings were surgically implanted around the superior mesenteric arteries to create gradual stenosis. Pre- and postoperative angiograms and pre- and postprandial magnetic resonance (MR) oximetry measurements of the SMV %HbO2, with flow-independent T2 measurements of venous blood, were obtained at different times.
In vivo magnetic resonance evaluation of blood oxygen saturation in the superior mesenteric vein as a measure of the degree of acute flow reduction in the superior mesenteric artery: findings in a canine model.
Acad Radiol
January 1997
Department of Radiology, Stanford University School of Medicine, CA, USA.
Rationale And Objectives: The authors tested the hypothesis that changes in oxygen saturation (%HbO2) in the superior mesenteric vein (SMV), as measured with in vivo magnetic resonance (MR) oximetry, correlate with the degree of acute superior mesenteric artery (SMA) flow reduction.
Methods: Ten mongrel dogs were studied. A catheter was inserted into the SMV, and a perivascular ultrasonic flow probe and an adjustable mechanical occluder were placed around the SMA.
Oxygen saturation of blood in the superior mesenteric vein: in vivo verification of MR imaging measurements in a canine model. Work in progress.
Radiology
February 1995
Department of Radiology, Stanford University School of Medicine, CA 94305.
Purpose: To evaluate the accuracy of magnetic resonance (MR) imaging in estimating oxygen saturation of blood (%HbO2) in the superior mesenteric vein (SMV) of a canine model in vivo.
Materials And Methods: MR imaging was used to measure the T2 of blood in samples obtained via a catheter placed in the SMV in seven mongrel dogs. %HbO2 was measured with a reflectance oximeter.
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