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Deep learning based predictive modeling to screen natural compounds against TNF-alpha for the potential management of rheumatoid arthritis: Virtual screening to comprehensive in silico investigation.
PLoS One
December 2024
Department of Biomedical Engineering, Military Institute of Science and Technology (MIST), Dhaka, Bangladesh.
Article Synopsis
- Rheumatoid arthritis (RA) affects 0.1% to 2.0% of people globally and conventional treatments can have serious side effects, highlighting a need for safer alternatives, particularly from natural sources.
- This study used deep learning to assess 2563 natural compounds for their ability to inhibit the TNF-α protein, which plays a key role in RA inflammation, achieving good prediction performance metrics.
- Four promising compounds—Imperialine, Veratramine, and Gelsemine—were identified as potential natural TNF-α inhibitors after thorough evaluation for drug-likeness and stability, showing low toxicity and effective binding energy results.
Influence of catheter thickness on respiratory physiology during less invasive surfactant administration in extremely preterm infants.
Front Pediatr
September 2024
Department of Neonatology, University Children's Hospital Tübingen, Tübingen, Germany.
Introduction: Delivering surfactant via thin catheters (minimal-invasive surfactant therapy (MIST); less invasive surfactant administration (LISA)) has become a common procedure. However, the effect of tracheal obstruction caused by catheters of different sizes on tracheal resistance in extremely low gestational age newborns (ELGANs) is unknown.
Methods: To investigate the effect of catheters size 3.
Virtually delivered Mindfulness-Oriented Recovery Enhancement (MORE) reduces daily pain intensity in patients with lumbosacral radiculopathy: a randomized controlled trial.
Pain Rep
April 2024
Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Introduction: Lumbosacral radiculopathy (LR), also known as sciatica, is a common type of radiating neurologic pain involving burning, tingling, and numbness in the lower extremities. It has an estimated lifetime prevalence as high as 43%.
Objectives: The objective of this randomized controlled trial was to evaluate the impact of virtually delivered Mindfulness-Oriented Recovery Enhancement (MORE) on patients with LR during the COVID-19 pandemic.
Effects of 3D virtual reality motionless imagery training program with an avatar.
Psych J
April 2023
Division of Sport Science, Pusan National University, Busan, Republic of Korea.
The present study aimed to explore the effects of motionless imagery training with an avatar in virtual reality (VR) on emotion, cognition, and physiological response changes in healthy adults. Participants were 30 healthy adults aged between 19 and 35 years. All participants were randomly divided into the experimental group (n = 18), which executed the imagery training with an avatar in VR, or the control group (n = 12), which merely experienced the VR without an avatar.
View Article and Find Full Text PDFBioprosthetic Aortic Valve Hemodynamics: Definitions, Outcomes, and Evidence Gaps: JACC State-of-the-Art Review.
J Am Coll Cardiol
August 2022
Columbia University Medical Center, New York, New York, USA.
A virtual workshop was organized by the Heart Valve Collaboratory to identify areas of expert consensus, areas of disagreement, and evidence gaps related to bioprosthetic aortic valve hemodynamics. Impaired functional performance of bioprosthetic aortic valve replacement is associated with adverse patient outcomes; however, this assessment is complicated by the lack of standardization for labelling, definitions, and measurement techniques, both after surgical and transcatheter valve replacement. Echocardiography remains the standard assessment methodology because of its ease of performance, widespread availability, ability to do serial measurements over time, and correlation with outcomes.
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