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Influence of heat treatment method on selected physicochemical and biological properties of fluoride-substituted calcium apatite.
Acta Bioeng Biomech
September 2024
Department of Biochemistry and Biotechnology, Medical University of Lublin, Lublin, Poland.
: The synthesis of fluoridated apatite consists of several stages, among which the heat treatment has a significant impact on the physical and chemical properties. The present study aims to elucidate the influence of two different sintering methods on fluoride-substituted apatite properties. : For this purpose, a two F-substituted apatites were produced by heat treatment in different ways called "rapid sintering" and "slow sintering".
View Article and Find Full Text PDFAcid-Triggered Dual-Functional Hydrogel Platform for Enhanced Bone Regeneration.
Adv Sci (Weinh)
January 2025
Medical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Stem cell implantation holds promise for enhancing bone repair, but risks of pathogen transmission and malignant cell transformation should not be ignored. Compared to stem cell implantation, recruitment of endogenous stem cells to injured sites is more critical for in situ bone regeneration. In this study, based on the acidic microenvironment of bone injury, an HG-AA-SDF-1α composite hydrogel with a dual-control intelligent switch function is developed by incorporating stromal cell-derived factor (SDF-1α), arginine carbon dots (Arg-CDs), and calcium ions (Ca) into the oxidized hyaluronic acid/gelatin methacryloyl (HG) hydrogel.
View Article and Find Full Text PDFEvaluation of self medication practices and prescription patterns in patients of chronic kidney disease: A cross-sectional, questionnaire based study.
Perspect Clin Res
August 2024
Department of Nephrology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Background: Pharmacotherapy of chronic kidney disease (CKD) consists of prescribing myriad of drugs such as antihypertensives, antidiabetics, and phosphate binders to delay disease progression and control the comorbidities, resulting in inherent variability in prescriptions. In addition, tendency to self-medicate may further aggravate the condition. Hence, the present study was planned to assess self-medication practices and variability in prescription patterns in CKD patients.
View Article and Find Full Text PDFInterplay of epilepsy and long-term potentiation: implications for memory.
Front Neurosci
January 2025
Department of Neurophysiology, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez", Mexico City, Mexico.
The interplay between long-term potentiation (LTP) and epilepsy represents a crucial facet in understanding synaptic plasticity and memory within neuroscience. LTP, a phenomenon characterized by a sustained increase in synaptic strength, is pivotal in learning and memory processes, particularly in the hippocampus. This review delves into the intricate relationship between LTP and epilepsy, exploring how alterations in synaptic plasticity mechanisms akin to those seen in LTP contribute to the hyperexcitable state of epilepsy.
View Article and Find Full Text PDFPredictive Laboratory Markers for Gastrointestinal Complications in Children with Henoch-Schönlein Purpura.
J Multidiscip Healthc
January 2025
Department of Rheumatology and Immunology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430016, People's Republic of China.
Background: Henoch-Schönlein Purpura (HSP) is a common systemic vasculitis in children that often involves the gastrointestinal system (GIS). Identifying reliable predictive markers for GIS complications is crucial for early intervention and improved patient outcomes.
Objective: This study aims to identify laboratory markers predictive of GIS complications in children with HSP using a machine learning approach.
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