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Escalation of intravenous fentanyl self-administration and assessment of withdrawal behavior in male and female mice.
Psychopharmacology (Berl)
December 2024
Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47904, USA.
Rationale: The rise in overdose deaths from synthetic opioids, especially fentanyl, necessitates the development of preclinical models to study fentanyl use disorder (FUD). While there has been progress with rodent models, additional translationally relevant models are needed to examine excessive fentanyl intake and withdrawal signs.
Objective: The current study aimed to develop a translationally relevant preclinical mouse model of FUD by employing chronic intravenous fentanyl self-administration (IVSA).
Solving the Global Opioid Crisis: Incorporating Genetic Addiction Risk Assessment with Personalized Dopaminergic Homeostatic Therapy and Awareness Integration Therapy.
J Addict Psychiatry
June 2024
Center for Exercise and Sport Mental Health, Western University Health Sciences, Pomona, USA.
Article Synopsis
- The opioid crisis has evolved into a global issue affecting various socioeconomic and cultural areas, with traditional treatment methods proving insufficient.
- A narrative review was conducted using multiple databases to explore the complex factors contributing to this epidemic, acknowledging the potential for bias in article selection.
- Despite some progress with Opioid Substitution Therapy, U.S. overdose deaths remain alarmingly high and are projected to increase; the authors suggest a need for a new treatment approach that targets brain neurotransmitter systems for better management.
Demystifying Death: Reflections on End-of-Life Doula Work.
Omega (Westport)
November 2024
Department of Sociology, Appalachian State University, Boone, NC, USA.
End-of-life doulas (EOLDs) represent a portion of a broader mobilization of end-of-life care practitioners to normalize discussions of death and assist dying persons and their caregivers in navigating the dying process. EOLDs primarily focus on creating a supportive environment for the dying and their loved ones. Research on the burgeoning care profession has documented the backgrounds and services of EOLD work; however, literature has overlooked EOLDs' personal reflections on their work.
View Article and Find Full Text PDFHow mortality awareness regulates intertemporal Choice: A joint effect of endpoint reminder and retrospective episodic thinking.
Conscious Cogn
November 2024
School of Humanities and Social Science, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China. Electronic address:
Although life is lived forward, it can only be understood backward. From the perspective of life-history theory, we propose that mortality reminders may induce backward thinking from the endpoint of life and regulate intertemporal choice between smaller-and-sooner (SS) and large-and-later rewards (LL), thereby helping individuals with time management. Experiment 1 compared the effects of mortality (endpoint) imagination with the imagination of being at age 70 and found that only mortality imagination significantly reduced delay discounting, the extent to which a delayed reward is discounted.
View Article and Find Full Text PDFAddiction Medicine: Opioid Use Disorder.
FP Essent
November 2024
Department of Clinical Sciences - Tilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX.
Most overdose deaths in the United States involve opioids. Identification and management of opioid use disorder by primary care physicians is a critical need in health care. Substance use disorders share neurobiological dysregulation of the central motivation and reward pathway (powered by dopamine) that manifests as a cycle of addiction driven by impulse and compulsion.
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