Unorthodox therapies are used also by MS-patients very frequently. Not all procedures are harmless affecting only the purse. The medical expert working within the German health care system will also be called for questions of compensation of costs. A survey of some paradigmatic unorthodox treatments is given. While the law and the jurisdiction concerning the public health insurance fund pronounce clear standards in respect to the demands on the efficacy shown by modern (biomathematic) methods, it is essentially a more difficult task to bring the jurisdiction of the Federal Supreme Court (BGH) in harmony with basic requirements of a rational and scientific medicine. The interindividual and intraindividual course of MS is most variable, therefore it is very difficult to make a distinction between natural course and effects of a therapy in a single case while the only possibility to estimate individual therapeutic chance is a statistic evidence of efficacy in general.
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Support Care Cancer
January 2025
Albert Einstein College of Medicine/Jacobi Medical Center, Building 1, 3N20, 1400 Pelham Parkway S, Bronx, NY, USA.
Purpose: One in four patients diagnosed with cancer are parents to dependent children. For these patients, childcare services are needed to overcome the time demands of cancer treatment. Despite the childcare support needs and its potential impact on treatment outcomes, targeted childcare services for cancer patients remain limited.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Flatiron Institute, Center for Computational Quantum Physics, New York, New York 10010, USA.
The exploration of quantum phases in moiré systems has drawn intense experimental and theoretical efforts. The realization of honeycomb symmetry has been a recent focus. The combination of strong interaction and honeycomb symmetry can lead to exotic electronic states such as fractional Chern insulator, unconventional superconductor, and quantum spin liquid.
View Article and Find Full Text PDFMol Ther Methods Clin Dev
March 2025
Immunologie-Oncologie, Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.
CD4CD8 TCRαβ (double-negative [DN]) T cells represent a rare T cell population that promotes immunological tolerance through various cytotoxic mechanisms. In mice, autologous transfer of DN T cells has shown protective effects against autoimmune diabetes and graft-versus-host disease. Here, we characterized human DN T cells from people living with type 1 diabetes (PWT1D) and healthy controls.
View Article and Find Full Text PDFJ Exp Clin Cancer Res
January 2025
Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a second-line treatment with curative potential for leukemia patients. However, the prognosis of allo-HSCT patients with disease relapse or graft-versus-host disease (GvHD) is poor. CD4 or CD8 conventional T (Tconv) cells are critically involved in mediating anti-leukemic immune responses to prevent relapse and detrimental GvHD.
View Article and Find Full Text PDFFront Immunol
January 2025
Team Immunity and Cancer, Cancer Research Center of Marseille (CRCM), Inserm U1068, CNRS UMR7258, Paoli-Calmettes Institute, University of Aix-Marseille UM105, Marseille, France.
Introduction: Acute myeloid leukemia (AML) is a rare haematological cancer with poor 5-years overall survival (OS) and high relapse rate. Leukemic cells are sensitive to Natural Killer (NK) cell mediated killing. However, NK cells are highly impaired in AML, which promote AML immune escape from NK cell immune surveillance.
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