We report the results of investigating a pregnant baboon that developed hypertension, proteinuria, and oedema in late gestation. Although the clinical presentation suggested a diagnosis of pre-eclampsia, the evolution of her clinical signs and results of a renal biopsy performed 3 weeks after delivery suggested that glomerulonephritis was the underlying disease.
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http://dx.doi.org/10.1111/j.1600-0684.1997.tb00054.x | DOI Listing |
J Dev Orig Health Dis
November 2024
Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Previous studies in rodents suggest that mismatch between fetal and postnatal nutrition predisposes individuals to metabolic diseases. We hypothesized that in nonhuman primates (NHP), fetal programming of maternal undernutrition (MUN) persists postnatally with a dietary mismatch altering metabolic molecular systems that precede standard clinical measures. We used unbiased molecular approaches to examine response to a high fat, high-carbohydrate diet plus sugar drink (HFCS) challenge in NHP juvenile offspring of MUN pregnancies compared with controls (CON).
View Article and Find Full Text PDFbioRxiv
September 2024
Department of Anthropology, Stony Brook University, Stony Brook, NY, USA.
Anim Behav
August 2024
Department of Biology, Duke University, Durham, NC, U.S.A.
The Vandenbergh effect, or male-mediated maturation, occurs when females reach sexual maturation upon exposure to a novel male. Male-mediated maturation is found across mammals, including in geladas, , where it may be an adaptive counterstrategy to infanticide that follows the immigration of a new male; maturing after male immigration maximizes a female's chances of weaning her first offspring before the next infanticidal male immigrates (the 'optimal timing hypothesis'). Alternatively, the nonadaptive 'Bruce effect by-product hypothesis' posits that male-mediated maturation in geladas (and possibly other mammals) is triggered by the same physiological changes that, in pregnant females, produce spontaneous abortion (the Bruce effect).
View Article and Find Full Text PDFJ Perinat Med
September 2023
Obstetrics, Gynecology and Genetics, Amarillo, TX, USA.
Objectives: studies of the bioavailability of major components of the tumor necrosis factor alpha (TNFα) biosystem inside the gestational sac during embryogenesis have not been reported. We sought to determine the concentration of TNFα, soluble (s) TNFα receptors (sTNFR1, sTNFR2), and RANTES in the primate extraembryonic celomic fluid (ECF).
Methods: A validated timed-pregnant baboon animal model (N: 10) for experimental research in pregnancy was used to collect paired maternal blood and ECF samples in ongoing pregnancies.
Mol Ther Nucleic Acids
September 2022
RNA Therapeutics Institute, University of Massachusetts Medical School, AS4-1049, 368 Plantation Street, Worcester, MA 01605, USA.
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